Clopamide
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Clinical data | |
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Trade names | Brinaldix |
AHFS/Drugs.com | International Drug Names |
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CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.010.238 |
Chemical and physical data | |
Formula | C14H20ClN3O3S |
Molar mass | 345.84 g·mol−1 |
3D model (JSmol) | |
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Clopamide (trade name Brinaldix) is a piperidine diuretic.[1]
Mechanism of action
Clopamide is categorised as a thiazide-like diuretic and works in similar way as the thiazide diuretics do. It acts in the kidneys, at the distal convoluted tubule (DCT) of the nephron where it inhibits the sodium-chloride symporter. Clopamide selectively binds at the chloride binding site of the sodium-chloride symporter in the PCT cells on the luminal (interior) side and thus interferes with the reabsorption of sodium chloride, causing an equiosmolar excretion of water along with sodium chloride.
References
Categories:
- Articles with short description
- Short description is different from Wikidata
- Articles with changed EBI identifier
- ECHA InfoCard ID from Wikidata
- Chemical pages without DrugBank identifier
- Drugs with no legal status
- Drugboxes which contain changes to verified fields
- Piperidines
- Sulfonamides
- Hydrazides
- Drugs developed by Novartis
- Diuretics
- Carbonic anhydrase inhibitors