Clear cell acanthoma

From WikiProjectMed
Jump to navigation Jump to search
Clear cell acanthoma
Clear cell acanthoma (Degos)

Clear cell acanthoma (also known as "Acanthome cellules claires of Degos and Civatte," "Degos acanthoma," and "Pale cell acanthoma") is a benign clinical and histological lesion initially described as neoplastic, which some authors now regard as a reactive dermatosis.

Signs and symptoms

It usually presents as a moist solitary firm, brown-red, well-circumscribed, 5 mm to 2 cm nodule or plaque on the lower extremities of middle-aged to elderly individuals The lesion has a crusted, scaly peripheral collarette and vascular puncta on the surface. It is characterized by slow growth, and may persist for years.


Clear cell acanthoma is characterized by a sharply demarcated psoriasiform epidermal hyperplasia composed of a proliferation of slightly enlarged keratinocytes, and basal cells with pale-staining glycogen-rich cytoplasm, mild spongiosis and scattered neutrophils, which may form small intraepidermal microabscesses. Oedematous dermal papillae are typically seen with increased vascularity and a mixed inflammatory infiltrate including lymphocytes, plasma cells and neutrophils.


Differential diagnosis

The clinical differential diagnosis includes: dermatofibroma, inflamed seborrheic keratosis, pyogenic granuloma, basal cell carcinoma, squamous cell carcinoma, verruca vulgaris, psoriatic plaque, and melanoma.


a) Clinical appearance of clear cell acanthoma before cryotherapy b) after 12 times of cryotherapy, the lesions resolved almost completely

Simple surgical excision is curative. [1]: 636 [2]: 777  Cryosurgery is the use of extreme cold in surgery to destroy abnormal or diseased tissue[3]Cryotherapy or cold therapy, is the local,as well as general use of low temperatures in medical therapy[4]

See also


  1. Odom, Richard B.; Davidsohn, Israel; James, William D.; Henry, John Bernard; Berger, Timothy G.; Clinical diagnosis by laboratory methods; Dirk M. Elston (2006). Andrews' diseases of the skin: clinical dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
  2. Freedberg, et al. (2003). Fitzpatrick's Dermatology in General Medicine. (6th ed.). McGraw-Hill. ISBN 0-07-138076-0.
  3. "Cryotherapy - DermNet New Zealand". Archived from the original on 2006-10-24. Retrieved 2022-04-12.
  4. Prohaska, Joseph; Jan, Abdul H. (2022). "Cryotherapy". StatPearls. StatPearls Publishing. Retrieved 12 April 2022.