Nevus comedonicus

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Nevus comedonicus syndrome
PMC4228659 IDOJ-5-520-g003.png
a) Nevus along Blaschko's lines over the chest, b) over leg
SymptomsClusters of small bumps filled with keratinous plugs[1]
Usual onsetBirth to age 15 years[1]
CausesGene mutation[1]
TreatmentPore-cleansing strips, squeezing the comedones, applying tretinoin, CO2 laser, surgery[1]
FrequencyRare, males=females[2]

Nevus comedonicus, also known as a comedo nevus, is characterized by a cluster of small bumps containing keratinous plugs resembling comedones.[1][2] It tends to occur more frequently on the face and neck and may present in a linear, Blaschkoid or segmental pattern.[3] It generally appears any time between birth and age 15 years, and is usually unilateral.[1]

It is caused by mutations during development of the unborn baby.[1] If nevus comedonicus occurs with eye, bone and nerve abnormalities, it is called Nevus comedonicus syndrome.[3]

Treatment is with pore-cleansing strips, squeezing the comedones, applying tretinoin and CO2 laser.[1] Cutting it out may be an option if the disease affects a small area.[1]

It is rare, males and females are affected equally, and around half present at birth.[2]

Signs and symptoms


(H and E staining) (a) ×10 multiple keratin-filled pits in the epidermis with mild hyperkeratosis, (b) ×40 scant atrophic sebaceous glands in the dermis

See also


  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 James, William D.; Elston, Dirk; Treat, James R.; Rosenbach, Misha A.; Neuhaus, Isaac (2020). "29. Epidermal nevi, neoplasms, and cysts". Andrews' Diseases of the Skin: Clinical Dermatology (13th ed.). Edinburgh: Elsevier. p. 637. ISBN 978-0-323-54753-6. Archived from the original on 2022-04-19. Retrieved 2022-04-18.
  2. 2.0 2.1 2.2 "Comedo naevus (comedone nevus): Causes, Images, and More - DermNet". Archived from the original on 2022-04-07. Retrieved 2022-04-18.
  3. 3.0 3.1 Zhu, Yong-Hang (2018). "27. Tumours of the skin". In Zhu, Wen-Yuan; Tan, Cheng; Zhang, Ru-zhi (eds.). Atlas of Skin Disorders: Challenging Presentations of Common to Rare Conditions. Springer. p. 480. ISBN 978-981-10-8036-4. Archived from the original on 2022-04-20. Retrieved 2022-04-18.