Amalgam tattoo

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Amalgam tattoo
Other names: Localized argyrosis,[1] focal argyrosis[2][nb 1]
Amalgamtätowierung IMG 1707.JPG
Amalgam tattoo in upper labial sulcus in an edentulous individual, left behind after teeth have been lost/extracted
SymptomsGrey, blue or black area in mouth[3]
CausesDenatl procedure[3]
Differential diagnosismelanoma[3]
TreatmentUsually none[3]

Amalgam tattoo is a grey, blue or black area of discoloration on the mucous membranes of the mouth, typically on the gums of the lower jaw due to entry of dental amalgam during a dental procedure.[3]

It is common, painless, and harmless, but it can be mistaken for melanoma.[3] Generally, no treatment is needed.[3]

Signs and symptoms

Amalgam tattoo usually occurs on the mandibular gingiva, often in an area in which an apicoectomy ("root-end filling") with amalgam was carried out.[4]: 138  After the gingiva, the alveolar mucosa and the buccal mucosa are the next most common sites, although any mucosal site in the mouth is possible.[1] It is painless, and appears as a blue-black or grey discolored macule on the surface of the mucosa.[4]: 138 [5]: 330 [6]: 183  The borders of the tattoo are variable, and may be well defined, irregular or diffuse.[1]


Amalgam tattoo is caused by implantation of amalgam into the tissues.[6]: 183  It may occur in several ways:

  • During placement of an amalgam filling,[6]: 183  e.g. if abrasions on the mucosa are present which allow entry of amalgam dust[1]
  • Shortly after placement of an amalgam filling, e.g. amalgam particles can contaminate dental floss and lead to linear amalgam tattoos in between the teeth, especially if flossing is carried out immediately after placement of an amalgam filling with a mesial or distal aspect[1]
  • Polishing of an amalgam filling
  • The pressure from high speed turbine dental drills can be enough to force amalgam particles into soft tissue,[1] as may occur when an old amalgam filling is being removed
  • When a tooth with an amalgam filling is extracted,[6]: 183  e.g. broken bits of amalgam filling falling into an extraction socket unnoticed[1]
  • When an amalgam filling is placed in the same appointment as a tooth extracted, as may occur in "quadrant dentistry"
  • Apicectomies are common causes of amalgam tattoo, since the amalgam is being placed inside the alveolus and the soft tissues are replaced on top[1]

Over time, the amalgam particles embedded in the soft tissues corrode.[6]: 183  Macrophages take up the exogenous particles, and the silver in amalgam leads to staining of collagen fibers.[6]: 183 

A similar appearance can be caused by implantation of graphite (e.g. from pencil leads), and is sometimes termed a graphite tattoo, although this is less common than tattooing with amalgam.[4]: 138 


The diagnosis is clinical.[4]: 138  Amalgam tattoo can be distinguished from other causes of localized oral pigmentation because it does not change significantly in size or color,[4]: 138  although it may appear to slowly enlarge for several months after the initial implantation of the metal particles.[1][6]: 183  Some amalgam tattoos appear radio-opaque on radiographs (i.e. they show up on x-rays),[4]: 138  although in many cases, amalgam tattoos have no radiographic features since the responsible particle(s) of amalgam are very small even though clinically the area of discolored mucosa is much larger.[1]

If necessary, the diagnosis can be confirmed histologically by excisional biopsy, which excludes nevi and melanomas.[4]: 138  If a biopsy is taken, the histopathologic appearance is:[1]

  • Pigmented fragments of metal within connective tissue
  • Staining of reticulin fibers with silver salts
  • A scattered arrangement of large, dark, solid fragments or a fine, black or dark brown granules
  • Large particles may be surrounded by chronically inflamed fibrous tissue
  • Smaller particles surrounded by more significant inflammation, which may be granulomatous or a mixture of lymphocytes and plasma cells


Theoretically, routine use of a dental dam during dental procedures which involve amalgam should reduce the risk of amalgam tattoo.[1]


No treatment is required since the lesion is entirely benign. Some suggest that amalgam tattoos are best surgically excised so as to ensure the lesion does not represent a melanoma.[4]: 138  Others say that excision should only be carried out if there is any doubt over the diagnosis, and that amalgam tattoos are managed by simple reassurance about the nature of the lesion.[5]: 330  For example, if radio-opaque particles are demonstrated on the x-ray, biopsy is unnecessary.[1]


Amalgam tattoo is found in up to 1% of people in the general population.[7] It is the most common cause of solitary or focal pigmentation of the oral mucosa.[7]


  1. Argyrosis is an uncommon synonym of argyria, a condition caused by excessive exposure to silver, where the skin and mucous membranes are discolored blue or black. Some have criticized these as inappropriate synonyms for amalgam tattoo since silver is just one of several components of dental amalgam (See Neville 2001)


  1. 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 Neville BW, Damm DD, Allen CA, Bouquot JE (2002). Oral & maxillofacial pathology (2nd ed.). Philadelphia: W.B. Saunders. pp. 269–272. ISBN 0721690033.
  2. Richard C.K. Jordan; Michael A.O. Lewis (2004). A color handbook of oral medicine. New York: Thieme. p. 131. ISBN 9781588902740. Archived from the original on 2021-08-27. Retrieved 2021-01-22.
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 Fehrenbach, Margaret J.; Minihan-Anderson, Kristin; Ibsen, Olga A. C.; Peters, Scott M. (2023). "2. Inflammation and repair: injuries to oral soft tissue". In Ibsen, Olga A. C.; Peters, Scott (eds.). Oral Pathology for the Dental Hygienist (8th ed.). St Louis, Missourie: Elsevier. p. 56. ISBN 978-0-323-76403-2. Archived from the original on 2022-05-26. Retrieved 2022-05-26.
  4. 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 Scully, Crispian (2013). Oral and maxillofacial medicine : the basis of diagnosis and treatment (3rd ed.). Edinburgh: Churchill Livingstone/Elsevier. ISBN 9780702049484.
  5. 5.0 5.1 Athanasios Kalantzis; Crispian Scully (2005). Oxford handbook of dental patient care (2nd ed.). New York: Oxford University Press. ISBN 9780198566236.
  6. 6.0 6.1 6.2 6.3 6.4 6.5 6.6 Paul Coulthard; et al. (2008). Master dentistry (2nd ed.). Edinburgh: Churchill Livingstone/Elsevier. ISBN 9780443068966.
  7. 7.0 7.1 Martin S. Greenberg; Michael Glick; Jonathan A. Ship (2008). Burket's oral medicine (11th ed.). Hamilton, Ont.: BC Decker. p. 124. ISBN 9781550093452. Archived from the original on 2021-08-27. Retrieved 2021-01-22.