List of soft tissue tumors

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This is a list of soft tissue tumors. The fifth edition (2020) WHO classification of soft tissue tumors categorizes soft tissue tumors by its histology.[1] Some new types have been introduced, based on their distinct biological behaviour, location, genetics and appearance.[2][3][4]

Soft tissue tumors
Family (class) Type Image
Adipocytic tumor[5] Lipoma
Lipomatosis of nerve
Lipoblastoma and lipoblastomatosis
Myolipoma of soft tissue
Chondroid lipoma
Spindle cell lipoma and pleomorphic lipoma
Atypical spindle cell / pleomorphic lipomatous tumour
Atypical lipomatous tumour / well-differentiated liposarcoma
Dedifferentiated liposarcoma
Myxoid liposarcoma
Pleomorphic liposarcoma
Myxoid pleomorphic liposarcoma
Fibroblastic and myofibroblastic tumors Nodular fasciitis
Proliferative fasciitis and proliferative myositis
Myositis ossificans and fibro-osseous pseudotumour of digits
Ischemic fasciitis
Fibrous hamartoma of infancy
Fibromatosis colli
Juvenile hyaline fibromatosis
Inclusion body fibromatosis
Fibroma of tendon sheath
Desmoplastic fibroblastoma Myofibroblastoma
Calcifying aponeurotic fibroma
EWSR1-SMAD3-positive fibroblastic tumour (emerging)
Cellular angiofibroma
Angiofibroma of soft tissue
Nuchal-type fibroma
Acral fibromyxoma Gardner fibroma
Palmar fibromatosis and plantar fibromatosis
Desmoid fibromatosis
Lipofibromatosis 96 Giant cell fibroblastoma
Dermatofibrosarcoma protuberans
Solitary fibrous tumour
Inflammatory myofibroblastic tumour
Low-grade myofibroblastic sarcoma
Superficial CD34-positive fibroblastic tumour
Myxoinflammatory fibroblastic sarcoma
Fibrosarcoma; Infantile fibrosarcoma, adult fibrosarcoma
Low-grade fibromyxoid sarcoma
Sclerosing epithelioid fibrosarcoma
So-called fibrohistiocytic tumors Tenosynovial giant cell tumor
Deep fibrous histiocytoma
Plexiform fibrohistiocytic tumor
Giant cell tumor of soft tissue
Vascular tumors Haemangiomas (Synovial haemangioma, Intramuscular angioma, Arteriovenous malformation/haemangioma, Venous haemangioma)
Anastomosing haemangioma
Epithelioid haemangioma
Lymphangioma and lymphangiomatosis
Tufted angioma and kaposiform haemangioendothelioma
Retiform haemangioendothelioma
Papillary intralymphatic angioendothelioma
Composite haemangioendothelioma
Kaposi sarcoma
Pseudomyogenic haemangioendothelioma
Epithelioid haemangioendothelioma
Pericytic (perivascular) tumours Glomus tumour
Myopericytoma, including myofibroma
Smooth muscle tumors Leiomyoma
EBV-associated smooth muscle tumour[4]
Inflammatory leiomyosarcoma
Skeletal muscle tumours Rhabdomyoma
Embryonal rhabdomyosarcoma
Alveolar rhabdomyosarcoma
Pleomorphic rhabdomyosarcoma
Spindle cell / sclerosing rhabdomyosarcoma
Gastrointestinal stromal tumour
Chondro-osseous tumours Soft tissue chondroma

Extraskeletal osteosarcoma

Peripheral nerve sheath tumours Schwannoma



Granular cell tumour

Dermal nerve sheath myxoma

Solitary circumscribed neuroma

Ectopic meningioma and meningothelial hamartoma

Benign triton tumour / neuromuscular choristoma

Hybrid nerve sheath tumour

Malignant peripheral nerve sheath tumour

Malignant melanotic nerve sheath tumour

Tumours of uncertain differentiation
Intramuscular myxoma
Juxta-articular myxoma
Deep (aggressive) angiomyxoma
Atypical fibroxanthoma
Angiomatoid fibrous histiocytoma
Ossifying fibromyxoid tumour
Myoepithelioma, myoepithelial carcinoma, and mixed tumour
Pleomorphic hyalinizing angiectatic tumour of soft parts
Haemosiderotic fibrolipomatous tumour
Phosphaturic mesenchymal tumour
NTRK-rearranged spindle cell neoplasm (emerging)
Synovial sarcoma
Epithelioid sarcoma
Alveolar soft part sarcoma
Clear cell sarcoma of soft tissue
Extraskeletal myxoid chondrosarcoma
Desmoplastic small round cell tumour
Extrarenal rhabdoid tumour
Intimal sarcoma
Undifferentiated sarcoma


  1. Bansal, Abhinav; Goyal, Surbhi; Goyal, Ankur; Jana, Manisha (October 2021). "WHO classification of soft tissue tumours 2020: An update and simplified approach for radiologists". European Journal of Radiology. 143: 109937. doi:10.1016/j.ejrad.2021.109937. ISSN 1872-7727. PMID 34547634. Archived from the original on 2022-07-01. Retrieved 2022-06-20.
  2. WHO Classification of Tumours Editorial Board, ed. (2020). "1. Soft tissue tumors". Soft Tissue and Bone Tumours: WHO Classification of Tumours. Vol. 3 (5th ed.). Lyon (France): International Agency for Research on Cancer. pp. 1–320. ISBN 978-92-832-4503-2.
  3. Houdek, Matthew T. (2023). "1. Approach to bone and soft tissue tumors". In Folpe, Andrew L.; Nielsen, Gunnlaugur Petur (eds.). Bone and Soft Tissue Pathology: A Volume in the Foundations in Diagnostic Pathology Series (2nd ed.). Philadelphia: Elsevier. ISBN 978-0-323-75871-0. Archived from the original on 2023-02-26. Retrieved 2023-06-13.
  4. 4.0 4.1 Nobori, Alexander K.; Dry, Sarah M. (2023). "6. Smooth muscle tumors". In Folpe, Andrew L.; Nielsen, Gunnlaugur Petur (eds.). Bone and Soft Tissue Pathology: A Volume in the Foundations in Diagnostic Pathology Series (2nd ed.). Philadelphia: Elsevier. pp. 161–174. ISBN 978-0-323-75871-0. Archived from the original on 2023-07-09. Retrieved 2023-07-08.
  5. Thway, Khin (January 2022). "What's new in adipocytic neoplasia?". Histopathology. 80 (1): 76–97. doi:10.1111/his.14548. ISSN 1365-2559. PMID 34958506. Archived from the original on 2023-02-25. Retrieved 2022-06-20.