List of soft tissue tumors

The fifth edition (2020) WHO classification of soft tissue tumors categorizes soft tissue tumors by its histology.^[1] Some new types have been introduced, based on their distinct biological behaviour, location, genetics and appearance.^[2]^[3]^[4]

Soft tissue tumors
Family (class)	Type	Image
Adipocytic tumor^[5]	Lipoma
	Lipomatosis
	Lipomatosis of nerve
	Lipoblastoma and lipoblastomatosis
	Angiolipoma
	Myolipoma of soft tissue
	Chondroid lipoma
	Spindle cell lipoma and pleomorphic lipoma
	Hibernoma
	Atypical spindle cell / pleomorphic lipomatous tumour
	Atypical lipomatous tumour / well-differentiated liposarcoma
	Dedifferentiated liposarcoma
	Myxoid liposarcoma
	Pleomorphic liposarcoma
	Myxoid pleomorphic liposarcoma
Fibroblastic and myofibroblastic tumors	Nodular fasciitis
	Proliferative fasciitis and proliferative myositis
	Myositis ossificans and fibro-osseous pseudotumour of digits
	Ischemic fasciitis
	Elastofibroma
	Fibrous hamartoma of infancy
	Fibromatosis colli
	Juvenile hyaline fibromatosis
	Inclusion body fibromatosis
	Fibroma of tendon sheath
	Desmoplastic fibroblastoma Myofibroblastoma
	Calcifying aponeurotic fibroma
	EWSR1-SMAD3-positive fibroblastic tumour (emerging)
	Angiomyofibroblastoma
	Cellular angiofibroma
	Angiofibroma of soft tissue
	Nuchal-type fibroma
	Acral fibromyxoma Gardner fibroma
	Palmar fibromatosis and plantar fibromatosis
	Desmoid fibromatosis
	Lipofibromatosis 96 Giant cell fibroblastoma
	Dermatofibrosarcoma protuberans
	Solitary fibrous tumour
	Inflammatory myofibroblastic tumour
	Low-grade myofibroblastic sarcoma
	Superficial CD34-positive fibroblastic tumour
	Myxoinflammatory fibroblastic sarcoma
	Fibrosarcoma; Infantile fibrosarcoma, adult fibrosarcoma
	Myxofibrosarcoma
	Low-grade fibromyxoid sarcoma
	Sclerosing epithelioid fibrosarcoma
So-called fibrohistiocytic tumors	Tenosynovial giant cell tumor
	Deep fibrous histiocytoma
	Plexiform fibrohistiocytic tumor
	Giant cell tumor of soft tissue
Vascular tumors	Haemangiomas (Synovial haemangioma, Intramuscular angioma, Arteriovenous malformation/haemangioma, Venous haemangioma)
	Anastomosing haemangioma
	Epithelioid haemangioma
	Lymphangioma and lymphangiomatosis
	Tufted angioma and kaposiform haemangioendothelioma
	Retiform haemangioendothelioma
	Papillary intralymphatic angioendothelioma
	Composite haemangioendothelioma
	Kaposi sarcoma
	Pseudomyogenic haemangioendothelioma
	Epithelioid haemangioendothelioma
	Angiosarcoma
Pericytic (perivascular) tumours	Glomus tumour
	Myopericytoma, including myofibroma
	Angioleiomyoma
Smooth muscle tumors	Leiomyoma
	Leiomyosarcoma
	EBV-associated smooth muscle tumour^[4]
	Inflammatory leiomyosarcoma
Skeletal muscle tumours	Rhabdomyoma
	Embryonal rhabdomyosarcoma
	Alveolar rhabdomyosarcoma
	Pleomorphic rhabdomyosarcoma
	Spindle cell / sclerosing rhabdomyosarcoma
	Ectomesenchymoma
Gastrointestinal stromal tumour
Chondro-osseous tumours	Soft tissue chondroma Extraskeletal osteosarcoma
Peripheral nerve sheath tumours	Schwannoma Neurofibroma Perineurioma Granular cell tumour Dermal nerve sheath myxoma Solitary circumscribed neuroma Ectopic meningioma and meningothelial hamartoma Benign triton tumour / neuromuscular choristoma Hybrid nerve sheath tumour Malignant peripheral nerve sheath tumour Malignant melanotic nerve sheath tumour
Tumours of uncertain differentiation
	Intramuscular myxoma
	Juxta-articular myxoma
	Deep (aggressive) angiomyxoma
	Atypical fibroxanthoma
	Angiomatoid fibrous histiocytoma
	Ossifying fibromyxoid tumour
	Myoepithelioma, myoepithelial carcinoma, and mixed tumour
	Pleomorphic hyalinizing angiectatic tumour of soft parts
	Haemosiderotic fibrolipomatous tumour
	Phosphaturic mesenchymal tumour
	NTRK-rearranged spindle cell neoplasm (emerging)
	Synovial sarcoma
	Epithelioid sarcoma
	Alveolar soft part sarcoma
	Clear cell sarcoma of soft tissue
	Extraskeletal myxoid chondrosarcoma
	Desmoplastic small round cell tumour
	Extrarenal rhabdoid tumour
	PEComa
	Intimal sarcoma
	Undifferentiated sarcoma

References

↑ Bansal, Abhinav; Goyal, Surbhi; Goyal, Ankur; Jana, Manisha (October 2021). "WHO classification of soft tissue tumours 2020: An update and simplified approach for radiologists". European Journal of Radiology. 143: 109937. doi:10.1016/j.ejrad.2021.109937. ISSN 1872-7727. PMID 34547634. Archived from the original on 2022-07-01. Retrieved 2022-06-20.
↑ WHO Classification of Tumours Editorial Board, ed. (2020). "1. Soft tissue tumors". Soft Tissue and Bone Tumours: WHO Classification of Tumours. Vol. 3 (5th ed.). Lyon (France): International Agency for Research on Cancer. pp. 1–320. ISBN 978-92-832-4503-2.
↑ Houdek, Matthew T. (2023). "1. Approach to bone and soft tissue tumors". In Folpe, Andrew L.; Nielsen, Gunnlaugur Petur (eds.). Bone and Soft Tissue Pathology: A Volume in the Foundations in Diagnostic Pathology Series (2nd ed.). Philadelphia: Elsevier. ISBN 978-0-323-75871-0. Archived from the original on 2023-02-26. Retrieved 2023-06-13.
↑ ^4.0 ^4.1 Nobori, Alexander K.; Dry, Sarah M. (2023). "6. Smooth muscle tumors". In Folpe, Andrew L.; Nielsen, Gunnlaugur Petur (eds.). Bone and Soft Tissue Pathology: A Volume in the Foundations in Diagnostic Pathology Series (2nd ed.). Philadelphia: Elsevier. pp. 161–174. ISBN 978-0-323-75871-0. Archived from the original on 2023-07-09. Retrieved 2023-07-08.
↑ Thway, Khin (January 2022). "What's new in adipocytic neoplasia?". Histopathology. 80 (1): 76–97. doi:10.1111/his.14548. ISSN 1365-2559. PMID 34958506. Archived from the original on 2023-02-25. Retrieved 2022-06-20.

[Bansal2021-1] Bansal, Abhinav; Goyal, Surbhi; Goyal, Ankur; Jana, Manisha (October 2021). "WHO classification of soft tissue tumours 2020: An update and simplified approach for radiologists". European Journal of Radiology. 143: 109937. doi:10.1016/j.ejrad.2021.109937. ISSN 1872-7727. PMID 34547634. Archived from the original on 2022-07-01. Retrieved 2022-06-20.

[WHOblue2020.1.-2] WHO Classification of Tumours Editorial Board, ed. (2020). "1. Soft tissue tumors". Soft Tissue and Bone Tumours: WHO Classification of Tumours. Vol. 3 (5th ed.). Lyon (France): International Agency for Research on Cancer. pp. 1–320. ISBN 978-92-832-4503-2.

[Folpe2023.1-3] Houdek, Matthew T. (2023). "1. Approach to bone and soft tissue tumors". In Folpe, Andrew L.; Nielsen, Gunnlaugur Petur (eds.). Bone and Soft Tissue Pathology: A Volume in the Foundations in Diagnostic Pathology Series (2nd ed.). Philadelphia: Elsevier. ISBN 978-0-323-75871-0. Archived from the original on 2023-02-26. Retrieved 2023-06-13.

[Folpe2023.6-4] 4.0 ^4.1 Nobori, Alexander K.; Dry, Sarah M. (2023). "6. Smooth muscle tumors". In Folpe, Andrew L.; Nielsen, Gunnlaugur Petur (eds.). Bone and Soft Tissue Pathology: A Volume in the Foundations in Diagnostic Pathology Series (2nd ed.). Philadelphia: Elsevier. pp. 161–174. ISBN 978-0-323-75871-0. Archived from the original on 2023-07-09. Retrieved 2023-07-08.

[Thway2022-5] Thway, Khin (January 2022). "What's new in adipocytic neoplasia?". Histopathology. 80 (1): 76–97. doi:10.1111/his.14548. ISSN 1365-2559. PMID 34958506. Archived from the original on 2023-02-25. Retrieved 2022-06-20.

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List of soft tissue tumors

References

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