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Other names: Not recommended: Madelung disease, Launois-Bensaude syndrome[1]
TypesDiffuse lipomatosis, multiple symmetrical lipomatosis, pelvic lipomatosis, steroid lipomatosis, HIV lipodystrophy[1]

Lipomatosis is a type of smooth muscle tumor, where there is a generalised overgrowth of fatty tissue.[1] Types incude diffuse lipomatosis, multiple symmetrical lipomatosis, pelvic lipomatosis, steroid lipomatosis, and HIV lipodystrophy.[1]

It is believed to be an autosomal dominant condition in which multiple lipomas are present on the body. Many discrete, encapsulated lipomas form on the trunk and extremities, with relatively few on the head and shoulders.[2] In 1993, a genetic polymorphism within lipomas was localized to chromosome 12q15, where the HMGIC gene encodes the high-mobility-group protein isoform I-C.[3] This is one of the most commonly found mutations in solitary lipomatous tumors but lipomas often have multiple mutations. Reciprocal translocations involving chromosomes 12q13 and 12q14 have also been observed within.[4][5][6]

Although this condition is benign, it can sometimes be very painful depending on location of the lipomas. Some patients who are concerned with cosmetics seek removal of individual lipomas. Removal can include simple excision, endoscopic removal, or liposuction.[2]

Other entities which are accompanied by multiple lipomas include Proteus syndrome, Cowden syndrome and related disorders due to PTEN gene mutations, benign symmetric lipomatosis (Madelung disease), Dercum's Disease, familial lipodystrophy, hibernomas, epidural steroid injections with epidural lipomatosis,[7] and familial angiolipomatosis.

Signs and symptoms



"fatty tumor" (plural lipomata), 1830, medical Latin, from Greek lipos "fat" (n.), from PIE root *leip- "to stick, adhere," also used to form words for "fat," + -oma.

word-forming element expressing state or condition, in medical terminology denoting "a state of disease," from Latin -osis and directly from Greek -osis, formed from the aorist of verbs ending in -o. It corresponds to Latin -atio.

See also


  1. 1.0 1.1 1.2 1.3 1.4 WHO Classification of Tumours Editorial Board, ed. (2020). "1. Soft tissue tumours: Lipomatosis". Soft Tissue and Bone Tumours: WHO Classification of Tumours. Vol. 3 (5th ed.). Lyon (France): International Agency for Research on Cancer. pp. 16–17. ISBN 978-92-832-4503-2.
  2. 2.0 2.1 Toy, Brian R. (May 1, 2003). "Familial multiple lipomatosis". Dermatology Online Journal. 9 (4). Archived from the original on September 30, 2012. Retrieved October 3, 2022 – via
  3. Schoenmakers, EF; Wanschura, S; Mols, R; Bullerdiek, J; Van Den Berghe, H; Van De Ven, WJ (1995). "Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumours". Nature Genetics. 10 (4): 436–44. doi:10.1038/ng0895-436. PMID 7670494.
  4. Weiss, SW (1996). "Lipomatous tumors". Monographs in Pathology. 38: 207–39. PMID 8744279.
  5. Gologorsky, Y; Gologorsky, D; Yarygina, AS; Surti, U; Zirwas, MJ (2007). "Familial multiple lipomatosis: Report of a new family". Cutis; Cutaneous Medicine for the Practitioner. 79 (3): 227–32. PMID 17674589.
  6. Archived 2016-03-04 at the Wayback Machine Lipomatosis, Familial Multiple Lipomatosis, FML
  7. Archived 2014-09-24 at the Wayback Machine Multiple Epidural Steroid Injections and Epidural Lipomatosis

External links