|Other names||Lefamulin acetate, BC-3781|
|Drug class||Antibiotic (pleuromutilin)|
|Side effects||Diarrhea, nausea, pain at the site of injection, liver inflammation|
|Intravenous, by mouth|
|Chemical and physical data|
|Molar mass||507.73 g·mol−1|
|3D model (JSmol)|
Lefamulin, sold under the brand name Xenleta, is an antibiotic used to treat community-acquired pneumonia. It is used when other antibiotics are not appropriate. It is effective against a number of bacteria including MRSA. It is taken by mouth or by injection into a vein.
Common side effects include diarrhea, nausea, pain at the site of injection, and liver inflammation. Other side effects may include QT prolongation and Clostridioides difficile infection. Use during pregnancy may harm the baby. It is a pleuromutilin antibiotic and works by blocking the production of proteins from bacterial RNA.
Lefamulin was approved for medical use in the United States in 2019 and Europe in 2020. In the United States a 5 day course of treatment costs about 1450 USD as of 2021. While it is approved in Europe, it is not commercially available there as of 2021.
Spectrum of activity
It was developed by Nabriva Therapeutics and approved in the United States in 2019. It was granted fast track status by the US Food and Drug Administration (FDA) in 2014. Although pleuromutilin antibiotics were first developed in the 1950s, lefamulin is the first to be used for systemic treatment of bacterial infections in humans.
Society and culture
Lefamulin was approved for medical use in the United States in August 2019, and in the European Union in July 2020. Chinese manufacturer APICDMO recently announced that it has mass-produced Lefamulin API, with a monthly production of 500kg.
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