Protein-coding gene in the species Homo sapiens
Leucine-rich repeat-containing G-protein coupled receptor 6 is a protein that in humans is encoded by the LGR6 gene .[5] [6] G-protein coupled receptors LGR4 and LGR5 , LGR6 is a Wnt signaling pathway mediator. LGR6 also acts as an epithelial stem cell marker in squamous cell carcinoma in mice in vivo. [7]
This gene encodes a member of the leucine-rich repeat -containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. The encoded protein is a glycoprotein hormone receptor with a large N-terminal extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for ligand binding. Alternative splicing of this gene results in multiple transcript variants .[6]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000133067 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042793 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Hsu SY, Kudo M, Chen T, Nakabayashi K, Bhalla A, van der Spek PJ, van Duin M, Hsueh AJ (Jan 2001). "The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7" . Mol Endocrinol . 14 (8): 1257–71. doi :10.1210/me.14.8.1257 PMID 10935549 . ^ a b "Entrez Gene: LGR6 leucine-rich repeat-containing G protein-coupled receptor 6" .^ Huang, Phillips Y.; Kandyba, Eve; Jabouille, Arnaud; Sjolund, Jonas; Kumar, Atul; Halliwill, Kyle; McCreery, Melissa; DelRosario, Reyno; Kang, Hio Chung (2017). "Lgr6 is a stem cell marker in mouse skin squamous cell carcinoma" . Nature Genetics . 49 (11): 1624–1632. doi :10.1038/ng.3957 . PMC 5662105 PMID 28945253 .
Further reading
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Res . 6 (9): 791–806. doi :10.1101/gr.6.9.791 PMID 8889548 . Takeda S, Kadowaki S, Haga T, et al. (2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Lett . 520 (1–3): 97–101. doi :10.1016/S0014-5793(02)02775-8 . PMID 12044878 . S2CID 7116392 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment" . Genome Res . 13 (10): 2265–70. doi :10.1101/gr.1293003 . PMC 403697 PMID 12975309 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1" . Nature . 441 (7091): 315–21. Bibcode :2006Natur.441..315G . doi :10.1038/nature04727 PMID 16710414 .
This article incorporates text from the United States National Library of Medicine , which is in the public domain .
