Class C GPCR

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7 transmembrane receptor (metabotropic glutamate family)
Identifiers
Symbol7tm_3
PfamPF00003
InterProIPR000337
PROSITEPDOC00754
TCDB9.A.14
OPM superfamily6
OPM protein4or2
CDDcd13953
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

The class C G-protein-coupled receptors (InterProIPR000337) are a class of G-protein coupled receptors that include the metabotropic glutamate receptors (InterProIPR000162) and several additional receptors.[1]

Structurally they are composed of four elements; an N-terminal signal sequence; a large hydrophilic extracellular agonist-binding region containing several conserved cysteine residues which could be involved in disulphide bonds; a shorter region containing seven transmembrane domains; and a C-terminal cytoplasmic domain of variable length.[1] This protein family includes metabotropic glutamate receptors, the extracellular calcium-sensing receptors, the gamma-amino-butyric acid (GABA) type B receptors, and the vomeronasal type-2 receptors.

Subfamilies

Calcium-sensing receptor-related

GABAB receptors

Metabotropic glutamate receptors

RAIG

Taste receptors

Orphan

Other

References

  1. ^ a b Bräuner-Osborne H, Wellendorph P, Jensen AA (2007). "Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors". Curr Drug Targets. 8 (1): 169–84. doi:10.2174/138945007779315614. PMID 17266540.