OPN1MW

OPN1MW
Identifiers
Aliases	OPN1MW, CBBM, CBD, COD5, GCP, GOP, OPN1MW1, opsin 1 (cone pigments), medium-wave-sensitive, opsin 1, medium wave sensitive
External IDs	OMIM: 300821 HomoloGene: 88332 GeneCards: OPN1MW
Gene location (Human) Chr. X chromosome (human) Band Xq28 Start 154,182,596 bp End 154,196,861 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in appendix blood urinary bladder myometrium coronary artery left coronary artery stomach aorta thoracic aorta body of stomach n/a More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity photoreceptor activity signal transducer activity G protein-coupled photoreceptor activity identical protein binding Cellular component integral component of membrane plasma membrane membrane photoreceptor outer segment integral component of plasma membrane photoreceptor disc membrane Biological process positive regulation of cytokinesis signal transduction visual perception retinoid metabolic process response to stimulus G protein-coupled receptor signaling pathway phototransduction detection of visible light cellular response to light stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2652 n/a Ensembl ENSG00000268221 n/a UniProt P04001 P0DN77 P0DN78 n/a RefSeq (mRNA) NM_000513 n/a RefSeq (protein) NP_001316996 NP_000504 NP_001041646 NP_000504.1 NP_001041646.1 NP_000504 NP_001041646 NP_000504.1 NP_001041646.1 NP_000504 NP_001041646 n/a Location (UCSC) Chr X: 154.18 – 154.2 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

Green-sensitive opsin is a protein that in humans is encoded by the OPN1MW gene. OPN1MW2 is a similar opsin.

See also

• Opsin

Further reading

• Applebury ML, Hargrave PA (1987). "Molecular biology of the visual pigments". Vision Res. 26 (12): 1881–95. doi:10.1016/0042-6989(86)90115-X. PMID 3303660. S2CID 34038855.
• Winderickx J, Sanocki E, Lindsey DT, et al. (1993). "Defective colour vision associated with a missense mutation in the human green visual pigment gene". Nat. Genet. 1 (4): 251–6. doi:10.1038/ng0792-251. PMID 1302020. S2CID 23127406.
• Neitz J, Neitz M, Jacobs GH (1990). "Analysis of fusion gene and encoded photopigment of colour-blind humans". Nature. 342 (6250): 679–82. doi:10.1038/342679a0. PMID 2574415. S2CID 4273929.
• Nathans J, Thomas D, Hogness DS (1986). "Molecular genetics of human color vision: the genes encoding blue, green, and red pigments". Science. 232 (4747): 193–202. Bibcode:1986Sci...232..193N. CiteSeerX 10.1.1.461.5915. doi:10.1126/science.2937147. PMID 2937147.
• Li ZY, Kljavin IJ, Milam AH (1995). "Rod photoreceptor neurite sprouting in retinitis pigmentosa". J. Neurosci. 15 (8): 5429–38. doi:10.1523/JNEUROSCI.15-08-05429.1995. PMC 6577619. PMID 7643192.
• Ladekjaer-Mikkelsen AS, Rosenberg T, Jørgensen AL (1996). "A new mechanism in blue cone monochromatism". Hum. Genet. 98 (4): 403–8. doi:10.1007/s004390050229. PMID 8792812. S2CID 11799731.
• Ferreira PA, Nakayama TA, Pak WL, Travis GH (1996). "Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin". Nature. 383 (6601): 637–40. Bibcode:1996Natur.383..637F. doi:10.1038/383637a0. PMID 8857542. S2CID 4304490.
• Vissers PM, Bovee-Geurts PH, Portier MD, et al. (1998). "Large-scale production and purification of the human green cone pigment: characterization of late photo-intermediates". Biochem. J. 330 (3): 1201–8. doi:10.1042/bj3301201. PMC 1219262. PMID 9494086.
• Bernstein SL, Wong P (1998). "Regional expression of disease-related genes in human and monkey retina". Mol. Vis. 4: 24. PMID 9815288.
• Hayashi T, Motulsky AG, Deeb SS (1999). "Position of a 'green-red' hybrid gene in the visual pigment array determines colour-vision phenotype". Nat. Genet. 22 (1): 90–3. doi:10.1038/8798. PMID 10319869. S2CID 1326234.
• Ueyama H, Kuwayama S, Imai H, et al. (2002). "Novel missense mutations in red/green opsin genes in congenital color-vision deficiencies". Biochem. Biophys. Res. Commun. 294 (2): 205–9. doi:10.1016/S0006-291X(02)00458-8. PMID 12051694.
• Zhu X, Brown B, Li A, et al. (2003). "GRK1-dependent phosphorylation of S and M opsins and their binding to cone arrestin during cone phototransduction in the mouse retina". J. Neurosci. 23 (14): 6152–60. doi:10.1523/JNEUROSCI.23-14-06152.2003. PMC 6740345. PMID 12853434.
• Bonilha VL, Hollyfield JG, Grover S, Fishman GA (2005). "Abnormal distribution of red/green cone opsins in a patient with an autosomal dominant cone dystrophy". Ophthalmic Genet. 26 (2): 69–76. doi:10.1080/13816810590968041. PMID 16020309. S2CID 24486298.

External links

• GeneReviews/NIH/NCBI/UW entry on Red-Green Color Vision Defects