GPR39

GPR39
Identifiers
Aliases	GPR39, G protein-coupled receptor 39
External IDs	OMIM: 602886 MGI: 1918361 HomoloGene: 20380 GeneCards: GPR39
Gene location (Human)
Chr.	Chromosome 2 (human)
End	132,646,582 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	125,801,599 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; sperm; ; ganglionic eminence; ; right uterine tube; ; internal globus pallidus; ; nucleus accumbens; ; lower lobe of lung; ; islet of Langerhans; ; rectum;
	Top expressed in
	yolk sac; ; spermatid; ; duodenum; ; stomach; ; seminal vesicula; ; jejunum; ; esophagus; ; epithelium of stomach; ; seminiferous tubule; ; ileum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; metal ion binding;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane;
Biological process	G protein-coupled receptor signaling pathway; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	2863
	71111
	ENSG00000183840
	ENSMUSG00000026343
	O43194
	Q5U431
	NM_001508
	NM_027677
	NP_001499
	NP_081953
	Wikidata
View/Edit Human	View/Edit Mouse

G-protein coupled receptor 39 is a protein that in humans is encoded by the GPR39 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000183840 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026343 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ McKee KK, Tan CP, Palyha OC, Liu J, Feighner SD, Hreniuk DL, Smith RG, Howard AD, Van der Ploeg LH (Mar 1998). "Cloning and characterization of two human G protein-coupled receptor genes (GPR38 and GPR39) related to the growth hormone secretagogue and neurotensin receptors". Genomics. 46 (3): 426–34. doi:10.1006/geno.1997.5069. PMID 9441746.
^ "Entrez Gene: GPR39 G protein-coupled receptor 39".

Popovics P, Stewart AJ (2011). "GPR39: A Zn2+-activated G protein-coupled receptor that regulates pancreatic, gastrointestinal and neuronal functions". Cell. Mol. Life Sci. 68 (1): 85–95. doi:10.1007/s00018-010-0517-1. PMID 20812023. S2CID 20170402.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Holst B, Holliday ND, Bach A, et al. (2005). "Common structural basis for constitutive activity of the ghrelin receptor family". J. Biol. Chem. 279 (51): 53806–17. doi:10.1074/jbc.M407676200. PMID 15383539.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Holst B, Egerod KL, Schild E, et al. (2007). "GPR39 signaling is stimulated by zinc ions but not by obestatin". Endocrinology. 148 (1): 13–20. doi:10.1210/en.2006-0933. PMID 16959833.
Lauwers E, Landuyt B, Arckens L, et al. (2006). "Obestatin does not activate orphan G protein-coupled receptor GPR39". Biochem. Biophys. Res. Commun. 351 (1): 21–5. doi:10.1016/j.bbrc.2006.09.141. PMID 17054911.
Egerod KL, Holst B, Petersen PS, et al. (2007). "GPR39 splice variants versus antisense gene LYPD1: expression and regulation in gastrointestinal tract, endocrine pancreas, liver, and white adipose tissue". Mol. Endocrinol. 21 (7): 1685–98. doi:10.1210/me.2007-0055. PMID 17488974.
Yasuda S, Miyazaki T, Munechika K, et al. (2007). "Isolation of Zn2+ as an endogenous agonist of GPR39 from fetal bovine serum". J. Recept. Signal Transduct. Res. 27 (4): 235–46. doi:10.1080/10799890701506147. PMID 17885920. S2CID 33411716.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000183840 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026343 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9441746-5] McKee KK, Tan CP, Palyha OC, Liu J, Feighner SD, Hreniuk DL, Smith RG, Howard AD, Van der Ploeg LH (Mar 1998). "Cloning and characterization of two human G protein-coupled receptor genes (GPR38 and GPR39) related to the growth hormone secretagogue and neurotensin receptors". Genomics. 46 (3): 426–34. doi:10.1006/geno.1997.5069. PMID 9441746.

[entrez-6] "Entrez Gene: GPR39 G protein-coupled receptor 39".

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