Darier sign

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Darier sign
Mastocytosis: Darier's sign

Darier sign[1] is a change observed after stroking lesions on the skin of a person with urticaria pigmentosa.[2][3]

In general, the skin becomes swollen, itchy and red. This is a result of compression of mast cells, which are hyperactive in these diseases. These mast cells release inflammatory granules which contain histamine. It is the histamine which is responsible for the response seen after rubbing the lesional skin.

It is named for the French dermatologist Ferdinand-Jean Darier (1856–1938) who first described it.[1][4]

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See also


  1. 1.0 1.1 Mosby's Pocket Dictionary of Medicine, Nursing & Health Professions (Ninth ed.). St. Louis, Missouri: Elsevier. 2024. p. 343. ISBN 978-0-323-83291-5. Archived from the original on 2023-06-30. Retrieved 2023-05-20.
  2. Freiman, Anatoli; Kalia, Sunil; O'Brien, Elizabeth A. (July 2006). "Dermatologic Signs". Journal of Cutaneous Medicine and Surgery. 10 (4): 175–182. doi:10.2310/7750.2006.00042.
  3. Skrabs, Cathrin Constanze (1 September 2002). "Darier Sign: A Historical Note". Archives of Dermatology. 138 (9): 1253–1254. doi:10.1001/archderm.138.9.1251. ISSN 0003-987X. Archived from the original on 13 June 2021. Retrieved 20 May 2023.
  4. Crissey, John Thorne; Parish, Lawrence C.; Holubar, Karl (2013). "Late nineteenth century French dermatology". Historical Atlas of Dermatology and Dermatologists. CRC Press. p. 75. ISBN 978-1-84184-864-8. Archived from the original on 2023-06-30. Retrieved 2023-05-20.