Peripheral edema

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Peripheral edema
Other names: Peripheral oedema,[1][2] dependent edema
Combinpedal Right to Left.jpg
Leg edema

Peripheral edema is edema (accumulation of fluid causing swelling) in tissues perfused by the peripheral vascular system, usually in the lower limbs. In the most dependent parts of the body (those hanging distally), it may be called dependent edema.


The condition is commonly associated with vascular and cardiac changes associated with aging.[3] It can be caused by many other conditions, including congestive heart failure, kidney failure, liver cirrhosis, portal hypertension, trauma, alcoholism, altitude sickness, pregnancy, hypertension, sickle cell anemia, a compromised lymphatic system or merely long periods of time sitting or standing without moving.[4]

Some medicines such as pregabalin) may also cause or worsen the condition.[5] Others include amlodipine.[citation needed]


Successful treatment depends on control of the underlying cause. Severe swelling can cause permanent damage to nerves, resulting in peripheral neuropathy. Many cases from temporary or minor causes resolve on their own, with no lasting damage.[5]


  1. 'Oedema' is the standard form defined in the Concise Oxford English Dictionary (2011); the spelling in the United States is 'edema'.
  2. "oedema". Oxford English Dictionary (3rd ed.). Oxford University Press. September 2005. (Subscription or UK public library membership required.)
  3. Hopcroft, Keith; Forte, Vincent (2020). "Swollen ankles". Symptom Sorter. Boca Raton: CRC Press. pp. 324–326. ISBN 978-0-367-46810-1. Archived from the original on 2023-09-19. Retrieved 2023-09-19.
  4. Cho S, Atwood J (2002). "Peripheral edema" (PDF). Am J Med. 113 (7): 580–6. doi:10.1016/S0002-9343(02)01322-0. PMID 12459405. Archived (PDF) from the original on 2023-05-01. Retrieved 2022-07-05.
  5. 5.0 5.1 "Lyrica – Pregabalin Capsule". Parke-Davis Division of Pfizer Incorporated. December 2016. Archived from the original on 27 November 2018. Retrieved 24 April 2017.

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