Tuberculosis radiology

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Radiology (X-rays) is used in the diagnosis of tuberculosis. Abnormalities on chest radiographs may be suggestive of, but are never diagnostic of TB, but can be used to rule out pulmonary TB.

Chest X-ray

Tuberculosis creates cavities visible in x-rays like this one in the patient's right upper lobe.

A posterior-anterior (PA) chest X-ray is the standard view used; other views (lateral or lordotic) or CT scans may be necessary.[citation needed]

In active pulmonary TB, infiltrates or consolidations and/or cavities are often seen in the upper lungs with or without mediastinal or hilar lymphadenopathy.[1] However, lesions may appear anywhere in the lungs. In HIV and other immunosuppressed persons, any abnormality may indicate TB or the chest X-ray may even appear entirely normal.[1]

Old healed tuberculosis usually presents as pulmonary nodules in the hilar area or upper lobes, with or without fibrotic scars and volume loss.[1] Bronchiectasis and pleural scarring may be present.[citation needed]

Nodules and fibrotic scars may contain slowly multiplying tubercle bacilli with the potential for future progression to active tuberculosis.[1] Persons with these findings, if they have a positive tuberculin skin test reaction, should be considered high-priority candidates for treatment of latent infection regardless of age. Conversely, calcified nodular lesions (calcified granuloma) pose a very low risk for future progression to active tuberculosis.[citation needed]

Abnormalities on chest radiographs may be suggestive of, but are never diagnostic of, TB.[1] However, if a person has a positive response to the tuberculin skin test and no symptoms of the disease, chest radiographs can be used to rule out the possibility of pulmonary TB.[citation needed]

CDC guidelines for evaluating CXR

The chest X-ray and classification worksheet by the Centers for Disease Control and Prevention (CDC) of the United States is designed to group findings into categories based on their likelihood of being related to TB or non-TB conditions needing medical follow-up.[2]

Normal findings

These are films that are completely normal, with no identifiable cardiothoracic or musculoskeletal abnormality.[citation needed]

Abnormal findings

Chest X-ray findings that can suggest active TB

This category comprises all findings typically associated with active pulmonary TB.[2] In the US, refugees or immigration applicants with any of the following findings must submit sputum specimens for examination.[2]

1. Infiltrate or consolidation - Opacification of airspaces within the lung parenchyma. Consolidation or infiltrate can be dense or patchy and might have irregular, ill-defined, or hazy borders.

2. Any cavitary lesion - Lucency (darkened area) within the lung parenchyma, with or without irregular margins that might be surrounded by an area of airspace consolidation or infiltrates, or by nodular or fibrotic (reticular) densities, or both. The walls surrounding the lucent area can be thick or thin. Calcification can exist around a cavity.

3. Nodule with poorly defined margins - Round density within the lung parenchyma, also called a tuberculoma. Nodules included in this category are those with margins that are indistinct or poorly defined (tree-in-bud sign[3]). The surrounding haziness can be either subtle or readily apparent and suggests coexisting airspace consolidation.

4. Pleural effusion - Presence of a significant amount of fluid within the pleural space. This finding must be distinguished from blunting of the costophrenic angle, which may or may not represent a small amount of fluid within the pleural space (except in children when even minor blunting must be considered a finding that can suggest active TB).

5. Hilar or mediastinal lymphadenopathy (bihilar lymphadenopathy) - Enlargement of lymph nodes in one or both hila or within the mediastinum, with or without associated atelectasis or consolidation.

6. Linear, interstitial disease (in children only) - Prominence of linear, interstitial (septal) markings.

7. Other - Any other finding suggestive of active TB, such as miliary TB. Miliary findings are nodules of millet size (1 to 2 millimeters) distributed throughout the parenchyma.

Chest X-ray findings that can suggest inactive TB

This category includes findings that are suggestive of prior TB, that is inactive. Assessments of the activity of TB cannot be made accurately on the basis of a single radiograph alone. If there is any question of active TB, sputum smears must be obtained. Therefore, any applicant might have findings grouped in this category, but still have active TB as suggested by the presence of signs or symptoms of TB, or sputum smears positive for AFB.[2]

The main chest X-ray findings that can suggest inactive TB are:[2]

1. Discrete fibrotic scar or linear opacity—Discrete linear or reticular densities within the lung. The edges of these densities should be distinct and there should be no suggestion of airspace opacification or haziness between or surrounding these densities. Calcification can be present within the lesion and then the lesion is called a "fibrocalcific" scar.

2. Discrete nodule(s) without calcification—One or more nodular densities with distinct borders and without any surrounding airspace opacification. Nodules are generally round or have rounded edges. These features allow them to be distinguished from infiltrates or airspace opacities. To be included here, these nodules must be noncalcified. Nodules that are calcified are included in the category "OTHER X-ray findings, No follow-up needed".

3. Discrete fibrotic scar with volume loss or retraction—Discrete linear densities with reduction in the space occupied by the upper lobe. Associated signs include upward deviation of the fissure or hilum on the corresponding side with asymmetry of the volumes of the two thoracic cavities.

4. Discrete nodule(s) with volume loss or retraction—One or more nodular densities with distinct borders and no surrounding airspace opacification with reduction in the space occupied by the upper lobe. Nodules are generally round or have rounded edges.

5. Other—Any other finding suggestive of prior TB, such as upper lobe bronchiectasis. Bronchiectasis is bronchial dilation with bronchial wall thickening.

Other chest X-ray findings

Follow-up needed

This category includes findings that suggest the need for a follow-up evaluation for non-TB conditions.[2]

  1. Musculoskeletal abnormalities - New bony fractures or radiographically apparent bony abnormalities that need follow-up.
  2. Cardiac abnormalities - Cardiac enlargement or anomalies, vascular abnormalities, or any other radiographically apparent cardiovascular abnormality of significant nature to require follow-up.
  3. Pulmonary abnormalities - Pulmonary finding of a non-TB nature, such as a mass, that needs follow-up.
  4. Other - Any other finding that the panel physician believes needs follow-up, but is not one of the above.

No follow-up needed

This category includes findings that are minor and not suggestive of TB disease. These findings require no follow-up evaluation.[2]

Chest x-ray of pleural thickening post-primary tuberculosis
  1. Pleural thickening - Irregularity or abnormal prominence of the pleural margin, including apical capping (thickening of the pleura in the apical region). Pleural thickening can be calcified.
  2. Diaphragmatic tenting - A localized accentuation of the normal convexity of the hemidiaphragm as if "pulled upwards by a string."
  3. Blunting of costophrenic angle (in adults)—Loss of sharpness of one or both costophrenic angles. Blunting can be related to a small amount of fluid in the pleural space or to pleural thickening and, by itself, is a non-specific finding (except in children, when even minor blunting may suggest active TB). In contrast a large pleural effusion, or the presence of a significant amount of fluid in the pleural space, may be a sign of active TB at any age.
  4. Solitary calcified nodules or granuloma - Discrete calcified nodule or granuloma, or calcified lymph node. The calcified nodule can be within the lung, hila, or mediastinum. The borders must be sharp, distinct, and well defined. This was considered a Class B3 TB in the past; however, Class B3 has been omitted from the classification scheme because it has not been found to be associated with active TB.
  5. Minor musculoskeletal findings - Minor findings needing no follow-up.
  6. Minor cardiac findings - Minor findings needing no follow-up.

Extrapulmonary tuberculosis

CT scan of peritoneal tuberculosis, a form of extrapulmonary tuberculosis. The omentum and peritoneal surfaces are thickened (arrows).[4]

Peritoneal tuberculosis may mimic peritoneal carcinomatosis on CT scan.[4]

There is low-quality evidence that abdominal ultrasound has 63% sensitivity and 68% specificity in diagnosing abdominal tuberculosis when tuberculosis is bacteriologically confirmed in HIV-positive individuals. Therefore, a negative abdominal ultrasound finding does not rule out the disease due to its low sensitivity.[5]


  1. 1.0 1.1 1.2 1.3 1.4 Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; & Mitchell, Richard N. (2007). Robbins Basic Pathology (8th ed.). Saunders Elsevier. pp. 516-522 ISBN 978-1-4160-2973-1
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 "Instructions to Panel Physicians for Completing New U.S. Department of State MEDICAL EXAMINATION FOR IMMIGRANT OR REFUGEE APPLICANT (DS-2053) and Associated WORKSHEETS (DS-3024, DS-3025, and DS-3026)" (PDF). Centers for Disease Control and Prevention. Archived (PDF) from the original on 2016-11-09. Retrieved 2023-04-10.
  3. Rossi, S. E.; Franquet, T.; Volpacchio, M.; Gimenez, A.; Aguilar, G. (1 May 2005). "Tree-in-Bud Pattern at Thin-Section CT of the Lungs: Radiologic-Pathologic Overview". Radiographics. 25 (3): 789–801. doi:10.1148/rg.253045115. PMID 15888626. Archived from the original on 15 June 2012. Retrieved 28 May 2012.
  4. 4.0 4.1 Akce, Mehmet; Bonner, Sarah; Liu, Eugene; Daniel, Rebecca (2014). "Peritoneal Tuberculosis Mimicking Peritoneal Carcinomatosis". Case Reports in Medicine. 2014: 1–3. doi:10.1155/2014/436568. ISSN 1687-9627. PMC 3970461. PMID 24715911. CC-BY 3.0
  5. Van Hoving DJ, Griesel R, Meintjes G, Takwoingi Y, Maartens G, Ochodo EA (30 September 2019). "Abdominal ultrasound for diagnosing abdominal tuberculosis or disseminated tuberculosis with abdominal involvement in HIV-positive individuals". Cochrane Database of Systematic Reviews. 9 (9): CD012777. doi:10.1002/14651858.CD012777.pub2. PMC 6766789. PMID 31565799.

External links

  • Chest X-ray Atlas Archived 2023-03-06 at the Wayback Machine - Select Diseases|Tuberculosis for TB CXR case studies (X-ray pictures showing cavities, infiltrates, scarring, pleural effusion, interstitial nodules of military TB, and TB spine) - from Loyola University Chicago Stritch School of Medicine ©
  • Teaching File[permanent dead link] Radiology of Tuberculosis