|Netupitant||NK1 receptor antagonist|
|Palonosetron||5-HT3 receptor antagonist|
|Main uses||Chemotherapy-induced nausea and vomiting|
|Side effects||Headache, constipation, tiredness|
|By mouth, intravenous|
Netupitant/palonosetron, sold under the brand name Akynzeo, is a combination medication for prevention of acute and delayed chemotherapy-induced nausea and vomiting. It is taken by mouth. It is used with dexamethasone.
Common side effects include headache, constipation, and tiredness. The dose does not need to be adjusted in those with mild to moderate liver or kidney problems. Use is not recommended in pregnancy. Netupitant is an NK1 receptor blocker and palonosetron is a 5-HT3 receptor blocker.
The combination was approved for medical use in the United States in 2014 and Europe in 2015. In the United Kingdom it costs the NHS about £70 a dose as of 2021. In the United States this amount costs about 680 USD.
The most common side effects include headache, weakness, fatigue, upset stomach, constipation, and skin redness. The overall profile of adverse effects is comparable to that of palonosetron (see Palonosetron#Adverse effects); no common adverse effects can be attributed to netupitant.
Netupitant/palonosetron was approved for use in the United States in October 2014. It was approved for use in the European Union in May 2015. The intravenous version was approved in the United States in April 2018.
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