HOXB8

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HOXB8
Identifiers
AliasesHOXB8, HOX2, HOX2D, Hox-2.4, homeobox B8
External IDsOMIM: 142963 MGI: 96189 HomoloGene: 7768 GeneCards: HOXB8
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_024016

NM_010461

RefSeq (protein)

NP_076921

NP_034591

Location (UCSC)Chr 17: 48.61 – 48.62 MbChr 11: 96.17 – 96.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Homeobox protein Hox-B8 is a protein that in humans is encoded by the HOXB8 gene.[5][6][7]

Function

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of Homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with colorectal cancer. Mice that have had the murine ortholog (see Homology (biology) § Orthology) of this gene knocked out exhibit an excessive pathologic grooming behavior. This behavior is similar to the hair-pulling behavior of humans suffering from trichotillomania (TTM).[7]

Transplantation of normal (wild-type) bone marrow into a Hoxb8 mutant mouse results in a reduction of compulsive grooming.[8]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000120068 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000056648 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ McAlpine PJ, Shows TB (Jul 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
  6. ^ Scott MP (Nov 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. S2CID 13370372.
  7. ^ a b "Entrez Gene: HOXB8 homeobox B8".
  8. ^ Chen SK, Tvrdik P, Peden E, Cho S, Wu S, Spangrude G, Capecchi MR (May 2010). "Hematopoietic origin of pathological grooming in Hoxb8 mutant mice". Cell. 141 (5): 775–85. doi:10.1016/j.cell.2010.03.055. PMC 2894573. PMID 20510925.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.