CEBPG

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CEBPG
Identifiers
AliasesCEBPG, GPE1BP, IG/EBP-1, CCAAT/enhancer binding protein gamma, CCAAT enhancer binding protein gamma
External IDsOMIM: 138972 MGI: 104982 HomoloGene: 1368 GeneCards: CEBPG
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001806
NM_001252296

NM_009884

RefSeq (protein)

NP_001239225
NP_001797

NP_034014

Location (UCSC)Chr 19: 33.37 – 33.38 MbChr 7: 34.75 – 34.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CCAAT/enhancer-binding protein gamma (C/EBPγ) is a protein that in humans is encoded by the CEBPG gene.[5][6] This gene has no introns.

The C/EBP family of transcription factors regulates viral and cellular CCAAT/enhancer element-mediated transcription. C/EBP proteins contain the bZIP region, which is characterized by two motifs in the C-terminal half of the protein: a basic region involved in DNA binding and a leucine zipper motif involved in dimerization. The C/EBP family consist of several related proteins, C/EBPα, C/EBPβ, C/EBPγ, C/EBPδ, C/EBPζ, and C/EBPε, that form homodimers and that form heterodimers with each other. CCAAT/enhancer binding protein gamma may cooperate with Fos to bind the positive regulatory element-I (PRE-I) enhancer elements.[6][7]

C/EBPγ forms heterodimer with ATF4 for transcriptional activation of target genes in autophagy specifically to amino acid starvation.[8]

C/EBPγ along with its regulator, the trauma-induced transcription factor EGR1, plays an important role in the development of chronic pain and mechanical hypersensitivity after some types of injury or surgery.[9][10]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000153879 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000056216 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Williams SC, Cantwell CA, Johnson PF (Oct 1991). "A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro". Genes Dev. 5 (9): 1553–67. doi:10.1101/gad.5.9.1553. PMID 1884998.
  6. ^ a b "Entrez Gene: CEBPG CCAAT/enhancer binding protein (C/EBP), gamma".
  7. ^ Davydov, Ilia V.; Bohmann, Dirk; Krammer, Peter H.; Li-Weber, Min (1995). "Cloning of the cDNA encoding human C/EBPγ, a protein binding to the PRE-I enhancer element of the human interleukin-4 promoter". Gene. 161 (2): 271–275. doi:10.1016/0378-1119(95)00271-7. PMID 7665092.
  8. ^ Kim, Dongha; Kim, Junil; Yu, Young Suk; Kim, Yong Ryoul; Baek, Sung Hee; Won, Kyoung-Jae (Jul 2022). "Systemic approaches using single cell transcriptome reveal that C/EBPγ regulates autophagy under amino acid starved condition". Nucleic Acids Research. 50 (13): 7298–7309. doi:10.1093/nar/gkac593. PMC 9303372. PMID 35801910.
  9. ^ Mamet, Julien; Klukinov, Michael; Yaksh, Tony L.; Malkmus, Shelle A.; Williams, Samantha; Harris, Scott; Manning, Donald C.; Taylor, Bradley K.; Donahue, Renee R.; Porreca, Frank; Xie, Jennifer Y.; Oyarzo, Janice; Brennan, Timothy J.; Subieta, Alberto; Schmidt, William K.; Yeomans, David C. (2014). "Single intrathecal administration of the transcription factor decoy AYX1 prevents acute and chronic pain after incisional, inflammatory, or neuropathic injury". Pain. 155 (2): 322–333. doi:10.1016/j.pain.2013.10.015. PMID 24145208. S2CID 29286007.
  10. ^ Stephens, Kimberly E.; Moore, Cedric; Vinson, David A.; White, Bryan E.; Renfro, Zachary; Zhou, Weiqiang; Ji, Zhicheng; Ji, Hongkai; Zhu, Heng; Guan, Yun; Taverna, Sean D. (2022). "Identification of regulatory elements in primary sensory neurons involved in neuropathic pain". doi:10.1101/2022.09.09.507328. S2CID 252217024. {{cite journal}}: Cite journal requires |journal= (help)

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.