FOXP4

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FOXP4
Identifiers
AliasesFOXP4, hFKHLA, forkhead box P4
External IDsOMIM: 608924 MGI: 1921373 HomoloGene: 12536 GeneCards: FOXP4
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001110824
NM_001110825
NM_028767

RefSeq (protein)

NP_001012426
NP_001012427
NP_612466

NP_001104294
NP_001104295
NP_083043
NP_001390898
NP_001390899

Location (UCSC)Chr 6: 41.55 – 41.6 MbChr 17: 48.18 – 48.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Forkhead box protein P4 is a protein that in humans is encoded by the FOXP4 gene.[5]

This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Many members of the forkhead box gene family, including members of subfamily P, have roles in mammalian oncogenesis. This gene may play a role in the development of tumors of the kidney and larynx. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms.[5] It also is a major factor in developing Long COVID as such, increasing the chances of developing the little-understood syndrome 1.6 fold, a finding which has major implications for COVID-19 pandemic research.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000137166 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023991 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: FOXP4 forkhead box P4".
  6. ^ Ledford H (July 11, 2023). "Gene linked to long COVID found in analysis of thousands of patients". Nature. 619 (7970): 445. doi:10.1038/d41586-023-02269-2. PMID 37433943. S2CID 259831412 – via www.nature.com.

Further reading