TM-38837
(Redirected from TM38837)
This article may rely excessively on sources too closely associated with the subject, potentially preventing the article from being verifiable and neutral. (April 2011) |
Clinical data | |
---|---|
ATC code |
|
Identifiers | |
| |
CAS Number | |
PubChem CID | |
ChemSpider | |
Chemical and physical data | |
Formula | C30H25Cl2F3N4OS |
Molar mass | 617.51 g·mol−1 |
3D model (JSmol) | |
| |
|
TM-38837 is a small molecule inverse agonist/antagonist of the CB1 cannabinoid receptor, with peripheral selectivity. It is being developed for the treatment of obesity and metabolic disorders by 7TM Pharma.[1] The company has announced phase I clinical trials.
TM-38837 is among the first of a new generation of cannabinoid receptor antagonist designed to avoid the central nervous system liabilities of the first generation CB1 receptor antagonists such as rimonabant.[2]
See also
References
- ^ "7TM Pharma". Archived from the original on July 7, 2011. Retrieved January 18, 2011.
- ^ Hung MS, Chang CP, Li TC, Yeh TK, Song JS, Lin Y, et al. (September 2010). "Discovery of 1-(2,4-dichlorophenyl)-4-ethyl-5-(5-(2-(4-(trifluoromethyl)phenyl)ethynyl)thiophen-2-yl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide as a potential peripheral cannabinoid-1 receptor inverse agonist". ChemMedChem. 5 (9): 1439–43. doi:10.1002/cmdc.201000246. PMID 20652930. S2CID 34244587.
External links
Categories:
- Articles with short description
- Short description matches Wikidata
- Articles lacking reliable references from April 2011
- All articles lacking reliable references
- Drugs not assigned an ATC code
- Articles without EBI source
- Chemical pages without DrugBank identifier
- Articles without KEGG source
- Articles without UNII source
- Drugs with no legal status
- Articles containing unverified chemical infoboxes
- Anorectics
- CB1 receptor antagonists
- Peripherally selective drugs
- Alkyne derivatives
- Thiophenes
- Chloroarenes
- Trifluoromethyl compounds
- Pyrazoles
- All stub articles
- Cannabinoid stubs