AZD-1940
Jump to navigation
Jump to search
Clinical data | |
---|---|
Routes of administration | Oral |
Legal status | |
Legal status | |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
Chemical and physical data | |
Formula | C20H29F2N3O2S |
Molar mass | 413.53 g·mol−1 |
3D model (JSmol) | |
| |
|
AZD-1940 is a drug developed by AstraZeneca, that is a peripherally selective cannabinoid agonist which binds with high affinity to both the CB1 and CB2 receptors. It was developed for the treatment of neuropathic pain, but while it showed good peripheral selectivity in animal studies,[1] in human clinical trials it failed to show sufficient analgesic efficacy and produced unexpectedly strong side effects associated with central cannabinoid activity, and so was discontinued from further development.[2][3]
See also
References
- ^ Schou M, Varnäs K, Jucaite A, Gulyás B, Halldin C, Farde L (April 2013). "Radiolabeling of the cannabinoid receptor agonist AZD1940 with carbon-11 and PET microdosing in non-human primate". Nuclear Medicine and Biology. 40 (3): 410–4. doi:10.1016/j.nucmedbio.2012.10.011. PMID 23352602.
- ^ Kalliomäki J, Segerdahl M, Webster L, Reimfelt A, Huizar K, Annas P, et al. (January 2013). "Evaluation of the analgesic efficacy of AZD1940, a novel cannabinoid agonist, on post-operative pain after lower third molar surgical removal". Scandinavian Journal of Pain. 4 (1): 17–22. doi:10.1016/j.sjpain.2012.08.004. PMID 29913883. S2CID 49302159.
- ^ Kalliomäki J, Annas P, Huizar K, Clarke C, Zettergren A, Karlsten R, Segerdahl M (March 2013). "Evaluation of the analgesic efficacy and psychoactive effects of AZD1940, a novel peripherally acting cannabinoid agonist, in human capsaicin-induced pain and hyperalgesia". Clinical and Experimental Pharmacology & Physiology. 40 (3): 212–8. doi:10.1111/1440-1681.12051. PMID 23324098. S2CID 1630384.
Categories:
- Articles with short description
- Short description matches Wikidata
- Drugs with non-standard legal status
- Articles without EBI source
- Chemical pages without DrugBank identifier
- Articles without KEGG source
- Drugs missing an ATC code
- Articles containing unverified chemical infoboxes
- Cannabinoids
- Benzimidazoles
- Tert-butyl compounds
- Sulfonamides
- Peripherally selective drugs
- Experimental psychiatric drugs
- All stub articles
- Cannabinoid stubs