Poorly differentiated thyroid cancer
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| Poorly differentiated thyroid carcinoma | |
|---|---|
| Other names | PDTC |
| Specialty | Oncology  |
Poorly differentiated thyroid carcinoma is malignant neoplasm of follicular cell origin showing intermediate histopathological patterns between differentiated and undifferentiated thyroid cancers.[1]
Histopathology
- Presence of small cells with round nuclei and scant cytoplasm with a diffuse solid pattern
- Round or oval nests (insulae) or in trabeculae.
- Solid growth and presence of microfollicles, some of which contain dense colloid.
- Extrathyroidal extension and blood vessel invasion
- Foci of necrosis,
- Larger than 5 cm in greatest diameter at diagnosis
Epidemiology
- PDTC affects predominantly females about 55 years of age
References
- ^ Volante M, Collini P, Nikiforov YE, Sakamoto A, Kakudo K, Katoh R, Lloyd RV, LiVolsi VA, Papotti M, Sobrinho-Simoes M, Bussolati G, Rosai J (2007). "Poorly differentiated thyroid carcinoma: the Turin proposal for the use of uniform diagnostic criteria and an algorithmic diagnostic approach". Am J Surg Pathol. 31 (8): 1256–64. doi:10.1097/PAS.0b013e3180309e6a. PMID 17667551. S2CID 41666642.
External links
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