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Combination of
EthambutolAnti-tuberculosis medication
IsoniazidAnti-tuberculosis medication
PyrazinamideAnti-tuberculosis medication
RifampicinAnti-tuberculosis medication
Trade namesVoractiv, Rimstar, others
Clinical data
Defined daily dosenot established[1]

Ethambutol/isoniazid/pyrazinamide/rifampicin, also known as ethambutol/isoniazid/pyrazinamide/rifampin, is a medication used for tuberculosis.[2] It is a fixed dose combination of ethambutol, isoniazid, pyrazinamide, and rifampicin.[2] It is used either alone or with other antituberculosis medication.[2] It is taken by mouth.[2]

Side effects are those of the underlying medications.[2] Pyridoxine may be used to decrease the risk of numbness.[3] It is not recommended in people with liver problems or severe kidney problems.[4] Use may not be suitable in children.[2] It is unclear if use during pregnancy is safe.[4]

It is on the World Health Organization's List of Essential Medicines.[5] In the United Kingdom it costs the NHS 98.75 pounds for a typical month of medication as of 2015.[3] It is sold under the brand names Voractiv and Rimstar in the UK.[4]


The defined daily dose is not established.[1]


  1. 1.0 1.1 "WHOCC - ATC/DDD Index". Archived from the original on 1 August 2020. Retrieved 18 September 2020.
  2. 2.0 2.1 2.2 2.3 2.4 2.5 World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 142. hdl:10665/44053. ISBN 9789241547659.
  3. 3.0 3.1 British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. p. 403. ISBN 9780857111562.
  4. 4.0 4.1 4.2 "Rimstar Film-coated Tablet / Voractiv Film-coated Tablet - Summary of Product Characteristics (SPC) - (eMC)". February 2016. Archived from the original on 20 December 2016. Retrieved 18 December 2016.
  5. World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.

External links