Erythema multiforme major

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Erythema multiforme majus
Other names: Erythema multiforme majus[1]
Confluent epidermal necrosis - very high mag.jpg
Micrograph of confluent epidermal necrosis. H&E stain.

Erythema multiforme major is a form of rash with skin loss or epidermal detachment.

The term "erythema multiforme majus" is sometimes used to imply a bullous (blistering) presentation.[2]

According to some sources, there are two conditions included on a spectrum of this same disease process:

In this view, EM major, SJS and TEN are considered a single condition, distinguished by degree of epidermal detachment.[3][4]

However, a consensus classification separates erythema multiforme minor, erythema multiforme major, and SJS/TEN as three separate entities.[3]

Erythema multiforme major induced by eslicarbazepine- test showing a strong positive immediate reaction with carbamazepine and eslicarbazepine at 0.1 and 0.01%


  1. Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 978-1-4160-2999-1.
  2. Daniel J. Trozak; Dan J. Tennenhouse (1 October 2005). Dermatology skills for primary care: an illustrated guide. Humana Press. pp. 161–. ISBN 978-1-58829-489-0. Archived from the original on 21 June 2013. Retrieved 5 June 2010.
  3. 3.0 3.1 "Erythema Multiforme: eMedicine Emergency Medicine". 2019-02-02. Archived from the original on 2010-08-06. {{cite journal}}: Cite journal requires |journal= (help)
  4. Bastuji-Garin S, Rzany B, Stern RS, Shear NH, Naldi L, Roujeau JC (January 1993). "Clinical classification of cases of toxic epidermal necrolysis, Stevens-Johnson syndrome, and erythema multiforme". Arch Dermatol. 129 (1): 92–6. doi:10.1001/archderm.129.1.92. PMID 8420497.[permanent dead link]
5. Orphanet Journal of Rare Diseases 2010, 5:39 doi:10.1186/1750-1172-5-39

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