Erythema annulare centrifugum

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Erythema anulare centrifugum
Other names: Deep gyrate erythema, Erythema perstans, Palpable migrating erythema and SSuperficial gyrate erythema[1]

Erythema annulare centrifugum (EAC), is a descriptive term for a class of skin lesion[2] presenting redness (erythema) in a ring form (anulare) that spreads from a center (centrifugum). It was first described by Darier in 1916.[3][4][5] Many different terms have been used to classify these types of lesions and it is still controversial on what exactly defines EAC. Some of the types include annular erythema (deep and superficial), erythema perstans, erythema gyratum perstans, erythema gyratum repens, darier erythema (deep gyrate erythema) and erythema figuratum perstans.

Symptoms and signs

Occurring at any age these lesions appear as raised pink-red ring or bulls-eye marks. They range in size from 0.5–8 cm (0.20–3.15 in). The lesions sometimes increase size and spread over time and may not be complete rings but irregular shapes. Distribution is usually on the thighs and legs but can also appear on the upper extremities, areas not exposed to sunlight, trunk or face. Currently EAC is not known to be contagious, but as many cases are incorrectly diagnosed as EAC, it is difficult to be certain.


Often no specific cause for the eruptions is found. However, it is sometimes linked to underlying diseases and conditions such as:


Micrograph of erythema annulare centrifugum, showing a moderately intense superficial perivascular dermal lymphohistiocytic infiltrate with rare eosinophils, edema of papillary dermis, hyperkeratosis and focal epidermal spongiosis.

A skin biopsy can be performed to test for EAC; tests should be performed to rule out other possible diseases such as: pityriasis rosea, tinea corporis, psoriasis, nummular eczema, atopic dermatitis, drug reaction, erythema migrans and other rashes.

Differential diagnosis


No treatment is usually needed as they usually go away anywhere from months to years. The lesions may last from anywhere between 4 weeks to 34 years with an average duration of 11 months. If caused by an underlying disease or malignancy, then treating and removing the disease or malignancy will stop the lesions. It usually doesn't require treatment, but topical corticosteroids may be helpful[8] in reducing redness, swelling and itchiness.

Some supported and not supported methods of having an effect on EAC include:

  • Photosensitive so it can be moved/reduced with appropriate sunlight.
  • Vitamin D
  • Immune system - hence it will increase in size/number when the immune system is low or overloaded.
  • Hormone Drugs
  • Disulone
  • Stress reduction
  • Topical calcipotriol - a topical vitamin D derivative has been known to be beneficial


It is very rare and estimated to affect 1 in 100,000 per year.[citation needed] Because of its rarity the documentation, cases and information are sparse and not a huge amount is known for certain, meaning that EAC could actually be a set of many un-classified skin lesions. It is known to occur at all ages and all genders equally.[citation needed] Some articles state that women are more likely to be affected than men.[citation needed]

See also


  1. Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 978-1-4160-2999-1.
  2. Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. p. 277. ISBN 978-1-4160-2999-1.
  3. synd/488 at Who Named It?
  4. J. Darier. De l’érythème annulaire centrifuge (érythème papulo-circineé migrateuse et chronique) et de quelques éruptions analogues. Annales de dermatologie et de syphilographie, Paris, 1916-1917, 5: 57-58.
  5. Bressler GS, Jones RE (May 1981). "Erythema annulare centrifugum". J. Am. Acad. Dermatol. 4 (5): 597–602. doi:10.1016/S0190-9622(81)70063-X. PMID 7240469.
  6. Al Hammadi A, Asai Y, Patt ML, Sasseville D (April 2007). "Erythema annulare centrifugum secondary to treatment with finasteride". J Drugs Dermatol. 6 (4): 460–3. PMID 17668547.
  7. Weyers W, Diaz-Cascajo C, Weyers I (December 2003). "Erythema annulare centrifugum: results of a clinicopathologic study of 73 patients". Am J Dermatopathol. 25 (6): 451–62. doi:10.1097/00000372-200312000-00001. PMID 14631185.
  8. Enta T (November 1996). "Dermacase. Erythema annulare centrifugum". Can Fam Physician. 42: 2148, 2151. PMC 2146938. PMID 8939316.

External links

External resources