|Trade names||Vistogard, Xuriden|
|Main uses||Hereditary orotic aciduria, poisoning due to fluorouracil or capecitabine|
|Onset of action||Tmax = 2–3 hours|
|US NLM||Uridine triacetate|
|Metabolism||Pyrimidine catabolic pathway|
|Elimination half-life||2–2.5 hours|
|Chemical and physical data|
|Molar mass||370.314 g·mol−1|
|3D model (JSmol)|
Uridine triacetate, formerly known as vistonuridine, is a medication used to treat hereditary orotic aciduria and poisoning due to fluorouracil or capecitabine. For poisoning it should be used within 4 days and in an overdose may be used regardless of the presence of symptoms. It is taken by mouth.
Uridine triacetate was approved for medical use in the United States in 2015. It is not approved in Europe. In the United States it costs about 4,200 USD per 10 gram dose as of 2021. In the United States it is only available through specialty pharmacies. In Canada approval is required from the Health Canada Special Access Programme. Brand names include Vistogard and Xuriden.
For poisoning a dose of 10 gm four times per day for 5 days is typically used.
For hereditary orotic aciduria a dose of 60 mg/kg per day to a maximum of 8 gm per day is typically used.
Society and culture
The cost of the medication used to treat an overdose is about 84,000 USD in the United States as of 2021.
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