|Main uses||Gaucher's disease|
|Side effects||Shortness of breath, cough, headache, itchiness, rash|
|Typical dose||15 to 60 units/kg q 2 wks|
|Elimination half-life||3.6–10.4 min|
|Chemical and physical data|
|Molar mass||55597.4 g·mol−1 (unglycosylated)|
|(what is this?)|
Imiglucerase, sold under the brand name Cerezyme, is a medication used to treat Gaucher's disease. Specifically it is used for type I and III disease. It is given by injection into a vein. It is used long term.
Common side effects include shortness of breath, cough, headache, itchiness, and rash. Other side effects may include pulmonary hypertension, pneumonia, and allergic reactions. It is a form of the enzyme β-glucocerebrosidase produced by recombinant DNA technology.
Imiglucerase was approved for medical use in the United States in 1994 and Europe in 1997. In the United Kingdom 400 units costs the NHS about £1,100 as of 2021. In the United States this amount costs about 1,650 USD.
It is generally started at a dose of 60 units/kg every two weeks, which may be decreased down to 15 units/kg.
It is available in formulations containing 200 or 400 units per vial. It has an activity of 890,000 units/mg. A typical dose is 2.5U/kg three times per week, up to a maximum of 60 U/kg once every two weeks, and safety has been established from ages 2 and up.
The most common side effect is hypersensitivity, which occurs in about 3% of patients. It is associated with symptoms such as cough, shortness of breath, rashes, itching, and angiooedema. Less common side effects include dizziness, headache, nausea, diarrhoea, and reactions at the injection site; they are found in less than 1% of patients.
Society and culture
It is one of more expensive medications, with an annual cost of $200,000 per person in the United States.
In Canada a year of medication costs about 385,000 to 705,000 CAD for a 70 kg person per year.
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- "Cerezyme (imiglucerase for injection) Genzyme product data sheet" (PDF). Archived from the original (PDF) on 2003-06-05.
- Austria-Codex (in Deutsch). Vienna: Österreichischer Apothekerverlag. 2018. Cerezyme 400 U-Pulver für ein Konzentrat zur Herstellung einer Infusionslösung.
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- Alfred B. Engelberg, Aaron S. Kesselheim, and Jerry Avorn (November 12, 2009). "Perspective: Balancing Innovation, Access, and Profits — Market Exclusivity for Biologics". N Engl J Med. 361 (20): 1917–1919. doi:10.1056/NEJMp0908496. PMID 19828525.CS1 maint: uses authors parameter (link)
- Information, National Center for Biotechnology; Pike, U. S. National Library of Medicine 8600 Rockville; MD, Bethesda (August 2017). "Table 12, CDR Cost Comparison Table for Drug Therapies for GD1". www.ncbi.nlm.nih.gov. Retrieved 25 November 2021.
- Erin Ailworth; Robert Weisman (June 17, 2009). "Virus shuts Genzyme plant, holds up drugs for 8,000". The Boston Globe.