Respiratory syncytial virus G protein is a glycoprotein produced by respiratory syncytial virus .[1] [2] [3]
Some features of the G protein suggest it could be important to respiratory syncytial virus vaccine or antiviral drug target design. [4] [5]
Three schematics represent disease pathogenesis associated 1st schematic with no vaccine ,2nd schematic an F protein vaccine , 3rd schematic an F + G protein vaccine[6]
References
↑ Harcourt J, Alvarez R, Jones LP, Henderson C, Anderson LJ, Tripp RA (February 2006). "Respiratory syncytial virus G protein and G protein CX3C motif adversely affect CX3CR1+ T cell responses" . Journal of Immunology . 176 (3): 1600–8. doi :10.4049/jimmunol.176.3.1600 PMID 16424189 . ↑ Li XQ, Fu ZF, Alvarez R, Henderson C, Tripp RA (January 2006). "Respiratory syncytial virus (RSV) infects neuronal cells and processes that innervate the lung by a process involving RSV G protein" . Journal of Virology . 80 (1): 537–40. doi :10.1128/JVI.80.1.537-540.2006 . PMC 1317531 PMID 16352577 . ↑ Zlateva KT, Lemey P, Moës E, Vandamme AM, Van Ranst M (July 2005). "Genetic variability and molecular evolution of the human respiratory syncytial virus subgroup B attachment G protein" . Journal of Virology . 79 (14): 9157–67. doi :10.1128/JVI.79.14.9157-9167.2005 . PMC 1168771 PMID 15994810 . ↑ Li X, Sambhara S, Li CX, Ettorre L, Switzer I, Cates G, James O, Parrington M, Oomen R, Du RP, Klein M (March 2000). "Plasmid DNA encoding the respiratory syncytial virus G protein is a promising vaccine candidate" . Virology . 269 (1): 54–65. doi :10.1006/viro.2000.0186 PMID 10725198 . ↑ Anderson LJ, Jadhao SJ, Paden CR, Tong S (July 2021). "Functional Features of the Respiratory Syncytial Virus G Protein" . Viruses . 13 (7): 1214. doi :10.3390/v13071214 PMC 8310105 PMID 34372490 . ↑ Boyoglu-Barnum, Seyhan; Chirkova, Tatiana; Anderson, Larry J. (2019). "Biology of Infection and Disease Pathogenesis to Guide RSV Vaccine Development" . Frontiers in Immunology . 10 . doi :10.3389/fimmu.2019.01675/full . ISSN 1664-3224 .
Further reading
