40S ribosomal protein S29 is a protein that in humans is encoded by the RPS29gene.[5][6][7]
Function
Ribosomes, the organelles that catalyzeprotein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit and a member of the S14P family of ribosomal proteins. The protein, which contains a C2-C2 zinc finger-like domain that can bind to zinc, can enhance the tumor suppressor activity of Ras-related protein 1A (KREV1). It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[7]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Kondoh N, Noda M, Fisher RJ, Schweinfest CW, Papas TS, Kondoh A, Samuel KP, Oikawa T (August 1996). "The S29 ribosomal protein increases tumor suppressor activity of K rev-1 gene on v-K ras-transformed NIH3T3 cells". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1313 (1): 41–6. doi:10.1016/0167-4889(96)00052-3. PMID8781548.
^Frigerio JM, Dagorn JC, Iovanna JL (May 1995). "Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1262 (1): 64–8. doi:10.1016/0167-4781(95)00045-i. PMID7772601.
Coppock D, Kopman C, Gudas J, Cina-Poppe DA (March 2000). "Regulation of the quiescence-induced genes: quiescin Q6, decorin, and ribosomal protein S29". Biochemical and Biophysical Research Communications. 269 (2): 604–10. doi:10.1006/bbrc.2000.2324. PMID10708601.
Zhou ZD, Bao L, Liu DG, Li MQ, Ge YZ, Huang YL, Liu WY (February 2003). "Low content of protein S29 in ribosomes of human lung cancer cell line a549: detected by two-dimensional electrophoresis". Protein and Peptide Letters. 10 (1): 91–7. doi:10.2174/0929866033408273. PMID12625830.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC1847948. PMID17353931.
