Mitochondrial ribosomal protein L39

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MRPL39
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMRPL39, C21orf92, L39mt, MRP-L5, MRPL5, PRED22, PRED66, RPML5, MSTP003, mitochondrial ribosomal protein L39, L5mt
External IDsOMIM: 611845 MGI: 1351620 HomoloGene: 9679 GeneCards: MRPL39
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_017446
NM_080794

NM_017404
NM_001384093
NM_001384095
NM_001384096

RefSeq (protein)

NP_059142
NP_542984

NP_059100
NP_001371022
NP_001371024
NP_001371025

Location (UCSC)Chr 21: 25.59 – 25.61 MbChr 16: 84.51 – 84.53 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

39S ribosomal protein L39, mitochondrial is a protein that in humans is encoded by the MRPL39 gene.[5][6]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Two transcript variants encoding distinct isoforms have been described. A pseudogene corresponding to this gene is found on chromosome 5q.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000154719 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022889 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kenmochi N, Suzuki T, Uechi T, Magoori M, Kuniba M, Higa S, Watanabe K, Tanaka T (Sep 2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.
  6. ^ a b "Entrez Gene: MRPL39 mitochondrial ribosomal protein L39".

Further reading