MRPS7

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MRPS7
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMRPS7, MRP-S, MRP-S7, RP-S7, RPMS7, S7mt, bMRP27a, mitochondrial ribosomal protein S7, COXPD34
External IDsOMIM: 611974 MGI: 1354367 HomoloGene: 9321 GeneCards: MRPS7
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015971

NM_025305

RefSeq (protein)

NP_057055

NP_079581

Location (UCSC)Chr 17: 75.26 – 75.27 MbChr 11: 115.49 – 115.5 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

28S ribosomal protein S7, mitochondrial is a protein that in humans is encoded by the MRPS7 gene.[5]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. In the prokaryotic ribosome, the comparable protein is thought to play an essential role in organizing the 3' domain of the 16S rRNA in the vicinity of the P- and A-sites. Pseudogenes corresponding to this gene are found on chromosomes 8p and 12p.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000125445 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000046756 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: MRPS7 mitochondrial ribosomal protein S7".

Further reading