MRPS25

MRPS25
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J9M
Identifiers
Aliases	MRPS25, MRP-S25, RPMS25, mitochondrial ribosomal protein S25, COXPD50
External IDs	OMIM: 611987 MGI: 1928140 HomoloGene: 11207 GeneCards: MRPS25
Gene location (Human) Chr. Chromosome 3 (human) Band 3p25.1 Start 15,009,611 bp End 15,065,339 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 D1 Start 92,146,506 bp End 92,161,014 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell right lobe of thyroid gland left lobe of thyroid gland cerebellar hemisphere anterior pituitary gastrocnemius muscle right lobe of liver right uterine tube nucleus accumbens Brodmann area 9 Top expressed in otic placode yolk sac primitive streak secondary oocyte plantaris muscle facial motor nucleus abdominal wall endocardial cushion medullary collecting duct digastric muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural constituent of ribosome Cellular component ribosome mitochondrion mitochondrial inner membrane Biological process mitochondrial translational elongation mitochondrial translational termination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64432 64658 Ensembl ENSG00000131368 ENSMUSG00000014551 UniProt P82663 Q9D125 RefSeq (mRNA) NM_022497 NM_025578 RefSeq (protein) NP_071942 NP_079854 Location (UCSC) Chr 3: 15.01 – 15.07 Mb Chr 6: 92.15 – 92.16 Mb PubMed search
Wikidata
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28S ribosomal protein S25, mitochondrial is a protein that in humans is encoded by the MRPS25 gene.

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. A pseudogene corresponding to this gene is found on chromosome 4.

Further reading

• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kenmochi N, Suzuki T, Uechi T, et al. (2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.
• Hattori A, Okumura K, Nagase T, et al. (2001). "Characterization of long cDNA clones from human adult spleen". DNA Res. 7 (6): 357–66. doi:10.1093/dnares/7.6.357. PMID 11214971.
• Koc EC, Burkhart W, Blackburn K, et al. (2000). "A proteomics approach to the identification of mammalian mitochondrial small subunit ribosomal proteins". J. Biol. Chem. 275 (42): 32585–91. doi:10.1074/jbc.M003596200. PMID 10938081.

External links

• Overview of all the structural information available in the PDB for UniProt: P82663 (28S ribosomal protein S25, mitochondrial) at the PDBe-KB.