Mitochondrial ribosomal protein L17

MRPL17
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CQM, 3J7Y, 3J9M
Identifiers
Aliases	MRPL17, L17mt, LIP2, MRP-L17, MRP-L26, RPL17L, RPML26, mitochondrial ribosomal protein L17
External IDs	OMIM: 611830 MGI: 1351608 HomoloGene: 32526 GeneCards: MRPL17
Gene location (Human) Chr. Chromosome 11 (human) Band 11p15.4 Start 6,680,385 bp End 6,683,340 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 E3 Start 105,452,413 bp End 105,460,306 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium anterior pituitary left adrenal gland right ventricle right adrenal gland periodontal fiber left ventricle prefrontal cortex islet of Langerhans parotid gland Top expressed in blastocyst yolk sac morula otic placode lip neural tube seminal vesicula triceps brachii muscle saccule esophagus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural constituent of ribosome protein domain specific binding Cellular component ribosome intracellular anatomical structure mitochondrion mitochondrial large ribosomal subunit mitochondrial inner membrane Biological process mitochondrial translational elongation mitochondrial translational termination protein biosynthesis mitochondrial genome maintenance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 63875 27397 Ensembl ENSG00000158042 ENSMUSG00000030879 UniProt Q9NRX2 Q9D8P4 RefSeq (mRNA) NM_022061 NM_025301 RefSeq (protein) NP_071344 NP_079577 Location (UCSC) Chr 11: 6.68 – 6.68 Mb Chr 7: 105.45 – 105.46 Mb PubMed search
Wikidata
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39S ribosomal protein L17, mitochondrial is a protein that in humans is encoded by the MRPL17 gene.

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.

Further reading

• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Tchernev VT, Mansfield TA, Giot L, et al. (2002). "The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins". Mol. Med. 8 (1): 56–64. doi:10.1007/bf03402003. PMC 2039936. PMID 11984006.
• Kenmochi N, Suzuki T, Uechi T, et al. (2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.
• Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
• O'Brien TW, Fiesler SE, Denslow ND, et al. (2000). "Mammalian mitochondrial ribosomal proteins (2). Amino acid sequencing, characterization, and identification of corresponding gene sequences". J. Biol. Chem. 274 (51): 36043–51. doi:10.1074/jbc.274.51.36043. PMID 10593885.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.

External links

• Overview of all the structural information available in the PDB for UniProt: Q9NRX2 (39S ribosomal protein L17, mitochondrial) at the PDBe-KB.