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Polyembryoma of the ovary 2.jpg
Polyembryoma of the ovary, H&E stain
SpecialtyOncology, gynecology
SymptomsLump in the tummy, early puberty, irregular menstrual cycle, pain[1]
Usual onsetTeenagers, young adults[1]
TypesOvarian, testicular[1]

Polyembryoma is a very aggressive form of germ cell tumor in the ovaries of females and testis of males, typically in teenagers and young adults.[1] It may present with a lump in the tummy, early puberty, or irregular menstrual cycle.[1] Some have pain.[1]

Why it occurs is not well understood.[1] Polyembryoma has features of both yolk sac tumour and undifferentiated teratoma/embryonal carcinoma, with a characteristic finding of embryoid bodies lying in a loose mesenchymal stroma.

It is very rare.[1] It has been reported in association with Klinefelter syndrome.[2]


  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 "Polyembryoma - About the Disease - Genetic and Rare Diseases Information Center". rarediseases.info.nih.gov. Archived from the original on 23 November 2021. Retrieved 7 July 2022.
  2. Beresford L, Fernandez CV, Cummings E, Sanderson S, Ming-Yu W, Giacomantonio M (April 2003). "Mediastinal polyembryoma associated with Klinefelter syndrome". Journal of Pediatric Hematology/Oncology. 25 (4): 321–323. doi:10.1097/00043426-200304000-00011. PMID 12679648.

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