Mitochondrial ribosomal protein L30

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MRPL30
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMRPL30, L28MT, L30MT, MRP-L28, MRP-L30, MRPL28, MRPL28M, RPML28, mitochondrial ribosomal protein L30
External IDsOMIM: 611838 MGI: 1333820 HomoloGene: 32675 GeneCards: MRPL30
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016503
NM_145212
NM_145213

NM_027098
NM_001356482

RefSeq (protein)

NP_660213

NP_081374
NP_001343411

Location (UCSC)Chr 2: 99.18 – 99.2 MbChr 1: 37.93 – 37.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

39S ribosomal protein L30, mitochondrial is a protein that in humans is encoded by the MRPL30 gene.[5]

Function

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified at least two transcript variants encoding the same protein. Pseudogenes corresponding to this gene are found on chromosomes 6p and 12p.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000185414 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026087 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: MRPL30 mitochondrial ribosomal protein L30".

Further reading

External links

  • Overview of all the structural information available in the PDB for UniProt: Q8TCC3 (Human 39S ribosomal protein L30, mitochondrial (MRPL30)) at the PDBe-KB.