Mitochondrial ribosomal protein L19

MRPL19
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J7Y, 3J9M
Identifiers
Aliases	MRPL19, L19mt, MRP-L15, MRP-L19, MRPL15, RLX1, RPML15, mitochondrial ribosomal protein L19
External IDs	OMIM: 611832 MGI: 1926274 HomoloGene: 8851 GeneCards: MRPL19
Gene location (Human) Chr. Chromosome 2 (human) Band 2p12 Start 75,646,783 bp End 75,690,851 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6 C3|6 35.81 cM Start 81,934,832 bp End 81,942,939 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle right adrenal gland left adrenal gland rectum islet of Langerhans oocyte secondary oocyte Achilles tendon right ventricle right lobe of liver Top expressed in endocardial cushion medullary collecting duct otic placode atrioventricular valve atrium renal corpuscle ventromedial nucleus lateral hypothalamus somite Paneth cell More reference expression data BioGPS n/a
Gene ontology Molecular function structural constituent of ribosome Cellular component mitochondrial inner membrane ribosome nuclear membrane intracellular anatomical structure nucleus mitochondrion mitochondrial large ribosomal subunit Biological process mitochondrial translational elongation mitochondrial translational termination protein biosynthesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9801 56284 Ensembl ENSG00000115364 ENSMUSG00000030045 UniProt P49406 Q9D338 RefSeq (mRNA) NM_014763 NM_026490 RefSeq (protein) NP_055578 NP_080766 Location (UCSC) Chr 2: 75.65 – 75.69 Mb Chr 6: 81.93 – 81.94 Mb PubMed search
Wikidata
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39S ribosomal protein L19, mitochondrial is a protein that in humans is encoded by the MRPL19 gene.

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.

Further reading

• Nagase T, Miyajima N, Tanaka A, et al. (1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.
• Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Graack HR, Bryant ML, O'Brien TW (2000). "Identification of mammalian mitochondrial ribosomal proteins (MRPs) by N-terminal sequencing of purified bovine MRPs and comparison to data bank sequences: the large subribosomal particle". Biochemistry. 38 (50): 16569–77. doi:10.1021/bi991543s. PMID 10600119.
• Hoja MR, Wahlestedt C, Höög C (2000). "A visual intracellular classification strategy for uncharacterized human proteins". Exp. Cell Res. 259 (1): 239–46. doi:10.1006/excr.2000.4948. PMID 10942595.
• Suzuki T, Terasaki M, Takemoto-Hori C, et al. (2001). "Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria". J. Biol. Chem. 276 (24): 21724–36. doi:10.1074/jbc.M100432200. PMID 11279069.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.