List of WHO AWaRe antibiotics
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This is a list of infections and antibiotics as detailed in the WHO AWaRe classification in the World Health Organization's book The WHO AWaRe (Access, Watch, Reserve) antibiotic book (2022) .[1][2] It provides guidance on using antibiotics responsibly, and is aimed at reducing antimicrobial resistance.[1]
List
- List of WHO AWaRe antibiotics for common infections in primary care
- List of WHO AWaRe antibiotics for common infections in hospital
Common infections in primary care
| Infection | Symptom | Management | Advice | Image | Notes | AWaRe guidance |
|---|---|---|---|---|---|---|
| Bronchitis | Cough +/- fever[2] | Bronchodilators[2]
Antipyretics (paracetamol, ibuprofen)[2] Mucolytics[2] Antitussives[2] |
Cough may last weeks.[2]
Mostly viral and self-limiting.[2] Most resolve without treatment[2] |
|
Yellow/green sputum does not indicate bacterial infection.[2]
Investigations generally initially unnecessary in otherwise well adults.[3] |
No antibiotic in most cases.[1] |
| Acute otitis media[4] | Young children with ear pain[4]
Fever, discharge[2] Bulging red tympanic membrane[4] +/- Viral upper respiratory tract infection[4] |
Most resolve without treatment, particularly in high income countries.[5] | 
|
2017: 317 million worldwide
Some protection with pneumococcal vaccine, flu vaccine, Hib vaccine[4] Treatment duration: 5 days |
Amoxicillin (first)[4]
Amoxicillin/clavulanic acid (second)[4] | |
| Pharyngitis[6] | Sore throat[6]
Viral: + Cough, headache, muscle aches)[6] Bacterial: + Fever, cervical lymphadenopathy, exudate[6] |
Paracetamol, ibuprofen[6] | Most resolve without treatment.[6] | 
|
Antibiotics where rheumatic fever is endemic.[6]
>80% viral[6] |
Amoxicillin or phenoxymethylpenicillin (first)[6] |
| Clarithromycin[2] | ||||||
| Acute sinusitis[7] | .jpg)
|
Amoxicillin or amoxicillin/clavulanic acid[2] | ||||
| Dental infection | Amoxicillin or phenoxymethylpenicillin (first)[2] | |||||
| Acute localized lymphadenitis | Amoxicillin/clavulanic acid or cefalexin or cloxacillin[2] | |||||
| Mild community-acquired pneumonia | Amoxicillin or phenoxymethylpenicillin[2] | |||||
| COPD exacerbations | Amoxicillin (first), cefalexin (second), or doxycycline[2]
Amoxicillin/clavulanic acid if severe[2]
| |||||
| Infectious bloody diarrhoea or dysentery | Ciprofloxacin[2]
Azithromycin (second)[2] | |||||
| Enteric fever[1] | Ciprofloxacin or azithromycin or ceftriaxone [2] | |||||
| Urinary tract infection[1] | .png)
|
Nitrofurantoin or trimethoprim/sulfamethoxazole or trimethoprim or amoxicillin/clavulanic acid[1] | ||||
| Skin/soft tissue infections | 
|
amoxicillin/clavulanic acid or cefalexin or cloxacillin[1] | ||||
| Wounds/burns related infection[1] | 
|
amoxicillin /clavulanic acid or cefalexin or cloxacillin[1] |
Common infections in hospital
| Infection | Symptom | Management | Advice | Image | Notes | AWaRe guidance |
|---|---|---|---|---|---|---|
| Sepsis (adults) | Ceftriaxone or cefotaxime combined with gentamicin[2] | |||||
| Amikacin[2] |
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 Zanichelli, Veronica; Sharland, Michael; Cappello, Bernadette; Moja, Lorenzo; Getahun, Haileyesus; Pessoa-Silva, Carmem; Sati, Hatim; van Weezenbeek, Catharina; Balkhy, Hanan; Simão, Mariângela; Gandra, Sumanth; Huttner, Benedikt (1 April 2023). "The WHO AWaRe (Access, Watch, Reserve) antibiotic book and prevention of antimicrobial resistance". Bulletin of the World Health Organization. 101 (4): 290–296. doi:10.2471/BLT.22.288614. ISSN 0042-9686. Archived from the original on 7 May 2023. Retrieved 17 November 2023.
- ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 2.12 2.13 2.14 2.15 2.16 2.17 2.18 2.19 2.20 2.21 2.22 The WHO AWaRe (Access, Watch, Reserve) antibiotic book Archived 2023-08-13 at the Wayback Machine. Geneva: World Health Organization; 2022. Licence: CC BY-NC-SA 3.0 IGO.
- ↑ Smith, Maeve P.; Lown, Mark; Singh, Sonal; Ireland, Belinda; Hill, Adam T.; Linder, Jeffrey A.; Irwin, Richard S.; Adams, Todd M.; Altman, Kenneth W.; Azoulay, Elie; Barker, Alan F.; Blackhall, Fiona; Birring, Surinder S.; Bolser, Donald C.; Boulet, Louis-Philippe; Braman, Sidney S.; Brightling, Christopher; Callahan-Lyon, Priscilla; Chang, Anne B.; Cowley, Terrie; Davenport, Paul; El Solh, Ali A.; Escalante, Patricio; Field, Stephen K.; Fisher, Dina; French, Cynthia T.; Grant, Cameron; Harding, Susan M.; Harnden, Anthony; Hill, Adam T.; Irwin, Richard S.; Kahrilas, Peter J.; Kavanagh, Joanne; Lai, Kefang; Kahrilas, Peter J.; Lilly, Craig; Lown, Mark; Madison, J. Mark; Malesker, Mark A.; Mazzone, Stuart; McGarvey, Lorcan; Molasoitis, Alex; Murad, M. Hassan; Narasimhan, Mangala; Newcombe, Peter; Oppenheimer, John; Rosen, Mark; Rubin, Bruce; Russell, Richard J.; Ryu, Jay H.; Singh, Sonal; Smith, Jaclyn; Smith, Maeve P.; Tarlo, Susan M.; Vertigan, Anne E.; Weinberger, Miles (May 2020). "Acute Cough Due to Acute Bronchitis in Immunocompetent Adult Outpatients". Chest. 157 (5): 1256–1265. doi:10.1016/j.chest.2020.01.044. Archived from the original on 2023-12-04. Retrieved 2023-11-30.
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 The WHO AWaRe. pp. 36-45
- ↑ Venekamp, Roderick P; Sanders, Sharon L; Glasziou, Paul P; Rovers, Maroeska M (15 November 2023). "Antibiotics for acute otitis media in children". Cochrane Database of Systematic Reviews. 2023 (11). doi:10.1002/14651858.CD000219.pub5. Archived from the original on 16 November 2023. Retrieved 3 December 2023.
- ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 6.7 6.8 6.9 The WHO AWaRe. pp. 46-60
- ↑ The WHO AWaRe. pp. 61-71
Bibliograaphy
- The WHO AWaRe (Access, Watch, Reserve) antibiotic book. World Health Organization. 2022. Retrieved 4 December 2023.