Talk:Vanillylmandelic acid

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Chemical formula

The chemical formula in the box on the right looks wrong. I don't think there should be a nitrogen there. Also, I don't see any difference between this name and the name for homovanillic acid despite the extra OH group. 194.176.105.40 15:33, 29 April 2007 (UTC)[reply]

Chemical formula and molecular weight fixed, thank you. The IUPAC name is in fact different—there's an extra "hydroxy" here:

VMA: 2-hydroxy-2-(4-hydroxy-3-methoxy-phenyl)acetic acid
HVA: 2-(4-hydroxy-3-methoxy-phenyl)acetic acid

Thanks again for pointing this out. Fvasconcellos (t·c) 16:04, 29 April 2007 (UTC)[reply]

VMA production from MHPG

According to Eisenhofer, Kopin, and Goldstein ^[1] the metabolic pathway in the figure on the lower right may be incomplete:

Contrary to usual depictions of catecholamine metabolism, VMA is produced mainly by oxidation of 3-methoxy-4-hydroxyphenylglycol (MHPG), catalyzed by the sequential actions of alcohol and aldehyde dehydrogenases (Kopin, 1985)^[2]. This pathway is rarely considered. Instead, formation of VMA is usually and erroneously ascribed to sequential oxidative deamination of norepinephrine to the form 3,4-dihydroxymandelic acid (DHMA) followed by O-methylation of DHMA to form VMA. This fallacious depiction implies independent sources of MHPG and VMA. Momeara (talk) 13:03, 29 July 2014 (UTC)[reply]

References

^ Eisenhofer, G. (1 September 2004). "Catecholamine Metabolism: A Contemporary View with Implications for Physiology and Medicine". Pharmacological Reviews. 56 (3): 331–349. doi:10.1124/pr.56.3.1.
^ Kopin, IJ (1985 Dec). "Catecholamine metabolism: basic aspects and clinical significance". Pharmacological reviews. 37 (4): 333–64. PMID 3915090. {{cite journal}}: Check date values in: |date= (help)

Vanilmandelate and where to make mention of it

So, I saw a non-existent link to Vanilmandelate, in case someone confused the two substances, and it mentioned that both were shortened to VMA. This makes sense, as one would want to clarify that this article is not about Vanilmandelate, but with a broken link, it seemed cluttered, or messy. I am not an expert on this, so I don't think I could start a page on the substance. Instead, I removed the link. Even so, I would like to make mention of Vanilmandelate in case someone becomes confused about the two. I wouldn't know where to put this tidbit of information, however. Does anyone have any ideas for it, or any input?

Sheepyedits (talk) 19:45, 2 March 2017 (UTC)[reply]

[1] Eisenhofer, G. (1 September 2004). "Catecholamine Metabolism: A Contemporary View with Implications for Physiology and Medicine". Pharmacological Reviews. 56 (3): 331–349. doi:10.1124/pr.56.3.1.

[2] Kopin, IJ (1985 Dec). "Catecholamine metabolism: basic aspects and clinical significance". Pharmacological reviews. 37 (4): 333–64. PMID 3915090. {{cite journal}}: Check date values in: |date= (help)

[1]

[2]

Talk:Vanillylmandelic acid

Chemical formula

VMA production from MHPG

Vanilmandelate and where to make mention of it

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