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Copyvio
I moved the following list to here, because it seems to be WP:Copypaste from its source. It needs to be phrased in own words before reinsertion. Mikael Häggström (talk) 05:20, 19 November 2015 (UTC)[reply]
Medical Problems
Administration of estrogen vaginally may cause an aggravation of a preexisting condition such as[1]:
Blood clotting problems—Although worsening of a blood clotting condition is unlikely, some doctors do not prescribe vaginal estrogens for patients with blood clotting problems or a history of these problems.
Breast cancer (active, suspected, or past history)—Estrogens should not be used.
Certain cancers, including cancers of the breast, bone, or uterus (active or suspected)—Estrogens may interfere with the treatment of breast or bone cancer or worsen cancer of the uterus when these conditions are present.
Cholestatic jaundice (flow of bile from the liver is blocked), past history—Caution should be used when this condition is present.
Diabetes mellitus (sugar diabetes)—Estrogens may alter your body's response to sugar in your diet.
Endometriosis or Fibroid tumors of the uterus—Estrogens may worsen endometriosis or increase the size of fibroid tumors.
Gallbladder problems (gallstones)—Estrogens may increase your chance of getting a gallbladder attack.
Heart attack or Stroke (active or past history)—Estrogens should not be used.
Hepatic hemangioma (noncancerous tumors of the liver)—Estrogens may worsen this medical problem.
High blood pressure—Estrogens may worsen this medical problem.
Hypercalcemia (too much calcium in your blood)—Estrogens may worsen this medical problem.
Hypertriglyceridemia (too much triglycerides in your blood)—Estrogens may increase your chance of getting pancreatitis or other side effects.
Hypocalcemia (too little calcium in your blood)—Your doctor should treat the low calcium in your blood before starting estrogen therapy.
Irritation or infection of the vagina—Usually estrogens decrease infections or irritation of the vagina, but sometimes these conditions may become worse.
Lupus erythematosus, systemic (SLE or lupus)—Estrogens may worsen this medical problem.
Porphyria—Estrogens may worsen this medical problem.
Hypothyroidism —Estrogens may alter your body's response to your thyroid medication. Your doctor may alter the amount of thyroid replacement that you take while on estrogen therapy.
Unusual genital or vaginal bleeding of unknown causes—Use of estrogens may delay diagnosis or worsen the condition. The reason for the bleeding should be determined before estrogens are used.
