Talk:Tuberculosis management

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Wiki Education Foundation-supported course assignment

This article was the subject of a Wiki Education Foundation-supported course assignment, between 21 January 2020 and 15 May 2020. Further details are available on the course page. Student editor(s): Christinetranster. Peer reviewers: Npatel23.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 11:47, 17 January 2022 (UTC)[reply]

Great article - but headings are messed up

I am very impressed by the quality (and comprehensiveness) of this article. However, a blemish is the confusion in the heading formatting: notice how the "Drugs", "The standard regimen", "Non-compliance" etc. are bold, large and non-underlined. But then "Surgical treatment", "Nutrition", "Latent tuberculosis" etc. are larger, non-bold and underlined. I could try to fix this mess myself, but I am not a regular contributor and my edits may be reverted. Also, I am not familiar with the standard heading formatting in Wikipedia. I could change all the top-deadings to the style in "Nutrition", if that's OK with you. 213.243.137.56 (talk) 00:36, 16 February 2009 (UTC)[reply]

Removed: New and Innovative Possible treatment

Tuberculosis remains such a huge health problem and one of the greatest threats to world security and health. We must look for new ways to treat it. In my opinion, DOTS, just doesn't seem to be working. Koch described the pathophysiology over 100 years ago in Kiel, but still one third of the world is infected. So we have developed an approach using Inhalational Phytochemcials(KielMix) which may be the answer and the first results are described here. Other researchers are adopting the same approach. This approach may also allow mass treatment of TB victims as in Russian prisons. (E Sherry, S Sivananthan, PH Warnke et al. Inhalational phytochemicals as possible treatment for pulmonary tuberculosis: two case reports. Am J Infect Control. 2004 Oct;32(6):369-70). " --SpacemanAfrica 05:39, 29 January 2006 (UTC)[reply]

Neck Abscess

I have undergone surgery of (Lymph left side) neck abscess (6 to 8 cm containing thick pus) on 17th July 2006. Under Regular medicine (1cap+3tab). I am getting one more abscess (2 cm now) next to the the last one which is removed. I am unable to understand why even after having regular medicine i am getting the abscess second time.. Infection caused by Mycobacterium tuberculosis as per various tests. Please let me know anything to stop the growth of mass..Help me out..

We don't give medical advice on wikipedia. If you don't feel confident with your current doctor's diagnosis and/or treatment, I recommend you seek a second opinion Nil Einne 23:27, 29 September 2006 (UTC)[reply]

Vitamin D and tuberculosis

Where should this paragraph go? Does it belong in tuberculosis treatment or in vitamin D?

Vitamin D supplementation appears to have a beneficial effect on the treatment of tuberculosis, although the mechanism by which this happens is not entirely clear. In mice, the mechanism appears to be up-regulation of nitric oxide-mediated killing,[1] but this appears not to be the case in humans. Instead, in humans, vitamin D-mediated killing appears to happen via an antimicrobial peptide called cathelicidin.[2] Indeed, reduced levels of vitamin D may explain the increased susceptibility of African-Americans to tuberculosis,[2] and may also explain why phototherapy is effective for lupus vulgaris (tuberculosis of the skin),[3] a finding which won Niels Finsen the Nobel Prize in 1903, because skin exposed to sunlight naturally produces more vitamin D.
Right, I've created a nutrition section and pasted this into a specific subsection on vitamin D.

References

  1. ^ Rockett KA, Brookes R, Udalova I; et al. (1998). "1,25-Dihydroxyvitamin D3 induces nitric oxide synthase and suppresses growth of Mycobacterium tuberculosis in a human macrophage-like cell line". Infect Immunity. 66 (11): 5314–21. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  2. ^ a b Liu PT, Stenger S, Li H; et al. (2006). "Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response". Science. 311: 1770–3. PMID 16497887. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  3. ^ Finsen NR. (1986). Om anvendelse i medicinen af koncentrerede kemiske lysstraaler. Copenhagen, Denmark: Gyldendalske Boghandels Forlag.

Deviations from the standard regimen

I have removed the following paragraph because the information is already contained in the section on extra-pulmonary TB.--Gak 14:55, 27 November 2006 (UTC)[reply]

The current regimen has been validated for adults with pulmonary TB but is also used to treat TB in the rest of the body (except infection of the brain or spinal cord). The US recommendation is 2HRZ/7HR for extra-pulmonary TB, but this recommendation is based on slim evidence and is not supported by the WHO. The only published evidence for 2HRZ/7HR is for TB osteomyelitis in weight-bearing bones.

CDR-TB

It should be noted that the first case of completely drug resistant tuberculosis (CDR-TB) was discovered in February 2007 in Italy. As its name suggests, it is resistant to every antibiotic known today, and the justified to fuck concern is that, as the head of TB at WHO says, "we are as helpless against completely drug-resistant TB as we were in the 19th century, before antibiotics." (New Scientist, 24 March 2007) —The preceding unsigned comment was added by 124.148.76.126 (talk) 07:22, 17 April 2007 (UTC).[reply]

MDR-TB

Much of the information on MDR-TB is duplicated in the MDR-TB article. I suggest that most of this information be moved to the MDR-TB article. --Gak (talk) 05:26, 18 October 2008 (UTC)[reply]

Latent TB

This information is duplicated in the latent tuberculosis article and could all be merged with that article. --Gak (talk) 10:03, 18 October 2008 (UTC)[reply]

Tuberculosis

I have been treated for tuberculosis successfully for 6 months I did not have my card with me and where I went wanted to give me a tb test as a requirement but I thought I was told that I should never have one because it may activate the tuberculosis again if this true or is there anether reason I don't remember for me not to be able to have a tb test Jenn —Preceding unsigned comment added by 74.233.111.98 (talk) 01:35, 25 March 2009 (UTC)[reply]

Streptomycin

According to my medical school professor Streptomycin was taken off the list of 1st line drugs as of Dec 2008. Just a note to the author that they might want to amend the first line treatment regimine. —Preceding unsigned comment added by Medstudent2011 (talk • contribs) 06:48, 10 April 2009 (UTC)[reply]

Do you have a reference for this (e.g., WHO bulletin or journal article)? It would be nice to see this in black-and-white somewhere before making such a major change.--Gak (talk) 11:23, 3 September 2009 (UTC)[reply]

Self-administered therapy

The following paragraph of text was removed, because it makes some rather bold statements that really do not belong in an encyclopaedia unless adequately referenced.

Self-administered therapy (SAT), is another form of treatment for tuberculosis, however it does not have a reliable efficiency rate. Patients receiving SAT are known to be negligent in completing their treatment programs, resulting in relapses.

--Gak (talk) 11:23, 3 September 2009 (UTC)[reply]

Doctors in the US can force patients to take medicine?

Under the Non-Compliance section, the article states: "In countries where doctors are unable to compel patients to take their treatment (e.g., the UK), some say that urine testing only results in unhelpful confrontations with patients and does not help increase compliance. In countries where legal measures can be taken to force patients to take their medication (e.g., the US), then urine testing can be a useful adjunct in assuring compliance." I'm not seeing a source for this statement, and I've never heard an adult in the US being forced into medical treatment (except for mental illness or addiction). 173.49.90.61 (talk) 04:06, 16 December 2009 (UTC)[reply]

History of TB treatment

Would be nice if someone added a paragraph or two about the history of TB treatment. How was it treated before modern antibiotics were developed, and how successful were those treatments? 174.24.113.243 (talk) 16:52, 12 November 2010 (UTC)[reply]

Thioridazine

There is not any support to assert that Thioridazine is a effective drug against Mycobacterium tuberculosis. I strongly suggest that it must be removed of the list. Thioridazine is used against psicosis. See "Goodman & Gilman's: The Pharmacological Basis of Therapeutics", 11th edition, 2006, chapter 18. —Preceding unsigned comment added by 187.56.74.250 (talk) 19:06, 14 April 2011 (UTC)[reply]

WHO does not recommend delaying HIV treatment until TB treatment is finished.

Guidelines are here: http://whqlibdoc.who.int/publications/2012/9789241503006_eng.pdf and clearly state that "Antiretroviral treatment should be given to all HIV-positive TB patients as soon as possible within the first 8 weeks of commencing antituberculosis treatment, regardless of their CD4 cell-counts." — Preceding unsigned comment added by 203.192.155.18 (talk) 03:34, 22 May 2012 (UTC)[reply]

Removed mentions of unsubstantiated claims

Claims that Ukrainian herbal treatments, as well as "V-5 vaccine" treatments have any effects on TB are not backed by any scientific evidence (apart of a few flawed research papers published in dubious journals), hence removal.

Mention on perchlozone should be either removed or dissociated from mention of PA 824: though the latter is experimental it has already 100+ titles in pubmed and the amount of data on its efficacy and safety is mounting. When it comes to Perchlozone, however, despite of being registered by Russian pharmaceutical regulator, there is simply NO single paper on clinical research. Ddonchuk (talk) 11:17, 29 April 2013 (UTC)[reply]

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Tuberculosis management in the pre-RHZES era

Scope of article topic: The article topic is tuberculosis management but currently the article covers only tuberculosis management in the modern era (ie, the RHZES era). Tuberculosis management in the pre-RHZES era is a fascinating topic and one that fully deserves an overview in a "History" section of this article. The main article is History of tuberculosis, but this article needs a pre-RHZES section of several paragraphs. I am declaring here my aspiration to write up an overview with refs someday if I ever get time. In the meantime I note here that the information in the "Society and culture" section as of this writing is public health and health policy information, not popular culture information. This is another thing that deserves fixing. I lack time for it right now. Quercus solaris (talk) 02:47, 31 August 2018 (UTC)[reply]

Proposed merge of Totally drug-resistant tuberculosis into Tuberculosis management

The following discussion is closed. Please do not modify it. Subsequent comments should be made in a new section. A summary of the conclusions reached follows.
The result of this discussion was no consensus to merge, given the comments on the further proposal below. Shhhnotsoloud (talk) 08:13, 1 July 2022 (UTC)[reply]

These are not wholly distinct topics and would be better discussed in a single article rather than multiple different ones. WP:DUP and WP:OVERLAP. - || RuleTheWiki || (talk) 04:00, 23 April 2021 (UTC)[reply]

The discussion above is closed. Please do not modify it. Subsequent comments should be made on the appropriate discussion page. No further edits should be made to this discussion.

Proposed merge of Extensively drug-resistant tuberculosis into Tuberculosis management

The following discussion is closed. Please do not modify it. Subsequent comments should be made in a new section. A summary of the conclusions reached follows.
The result of this discussion was no consensus to merge. Shhhnotsoloud (talk) 08:13, 1 July 2022 (UTC)[reply]

Same rationale as for Totally drug-resistant tuberculosis as this is not a completely separate disease rather a subset of Tuberculosis. WP:DUP and WP:OVERLAP - || RuleTheWiki || (talk) 04:03, 23 April 2021 (UTC)[reply]

  • Oppose. We have lots of subarticles about types of diseases. XDR and TDR TB are independently notable concepts that warrant separate articles. Tom (LT) (talk) 10:51, 23 April 2021 (UTC)[reply]
    But we don't have articles about, for instance, Extensively drug-resistant influenza or Extensively drug-resistant malaria or Extensively drug-resistant staphylococcus aureus. We have articles for MRSA and VISA because they are specific drugs which those organisms are incredibly resilient to and hard to find alternatives, meanwhile a little longer treatment with Isoniazid and Rifabutin can usually cure most cases of these types of tuberculosis. - || RuleTheWiki || (talk) 17:47, 25 April 2021 (UTC)[reply]
  • I support a different merge. Hmmm... I think that XDR-TB, TDR-TB, and MDR-TB should be merged together, but not with TB management. There's no need for several articles on the same concept of drug-resistant TB.
littleb2009 (talk page) 21:14, 5 May 2021 (UTC)[reply]
The discussion above is closed. Please do not modify it. Subsequent comments should be made on the appropriate discussion page. No further edits should be made to this discussion.

Wiki Education assignment: Technical and Scientific Communication

This article was the subject of a Wiki Education Foundation-supported course assignment, between 22 August 2022 and 9 December 2022. Further details are available on the course page. Student editor(s): Pthoman (article contribs).

— Assignment last updated by Egladfelter (talk) 18:39, 23 September 2022 (UTC)[reply]

Missing important drugs

There is no mention of Delamanid, an approved drug for TB. Pretomanid is mentioned as "an experimental drug" even though it has received approval for us in combination with Bedaquiline (listed as "Third-line drugs (WHO group 5) include drugs that may be useful, but have doubtful or unproven efficacy" - which is misleading) and Linezolid as part of the BPaL regimen. Doctor Iceberg (talk) 04:23, 22 April 2023 (UTC)[reply]

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