Talk:Statin

Insulin resistance

@ElijahDShervey: added:

Given the shared pathogenic mechanisms of Type 2 Diabetes and Cardiovascular Disease, particularly hyperglycemia and hyperinsulinemia (doi:10.3389/fendo.2018.00002), controversy is raised over the efficacy of prescribing statins to patients at risk of atherosclerotic cardiovascular disease without first assessing for insulin resistance.

I note that the part of this sentence that says "controversy is raised [...]" is not referenced. The consensus (based on the available data) says that the benefits of statins outweigh the risk in this regard.[1] I am also unsure how "assess[ment] for insulin resistance" would be conducted - with fasting blood sugar, HbA1c or a euglycaemic hyperinsulinaemic clamp.

Another good source: doi:10.1007/s11892-017-0837-8. JFW | T@lk 13:42, 29 January 2020 (UTC)

Statins for covid-19

Is statin beneficial for covid-19? Theoretical benefits and harms. Two opposing views:

https://www.sciencedirect.com/science/article/pii/S187140212030326X?via%3Dihub

https://www.ajconline.org/article/S0002-9149(20)30823-7/fulltext

I found these from reference list:

https://emedicine.medscape.com/article/2500114-treatment

--ee1518 (talk) 23:29, 2 December 2020 (UTC)

Examples of "alternative therapies" and "unproven medical therapies"

Hi dear contributors,

Let's look at the following sentence :

'An unintended effect of the academic statin controversy has been the spread of scientifically questionable alternative therapies. Cardiologist Steven Nissen at Cleveland Clinic commented "We are losing the battle for the hearts and minds of our patients to Web sites..." promoting unproven medical therapies.'

I believe this declaration could be improved by stating exactly which alternative therapies are we talking about. The source given only tells us about : ezetimibe and unproven dietary supplements. Instead of generalizing, can we talk only about ezetimibe as being "not as effective" as it is stated in the article. And by the way, this source is a medical blog describing itself as a "useful and reliable source for new and important information about cardiovascular medicine and, occasionally, more general health, medicine, and science topics." but is not a well-established peer-reviewed scientific journal. The author may have written previously in The Lancet, but his articles on his blog seems to be no longer reviewed by peers.

Sincerely,

Xavharel (talk) 16:47, 28 October 2022 (UTC)

Statin Effects on Aggression: Mood, Personality, and Behaviour Changes During Treatment with Statins

Hello, I don't see anything about Statins' effects on behaviour:

"...lower cholesterol can cause behavioural changes in both men and women... Several studies have supported a potential link between irritability and statins, including a randomised controlled trial... It found that the drug increased aggression in post-menopausal women... In 2018, a study uncovered the same effect in fish. Giving statins to Nile tilapia made them more confrontational and – crucially – altered the levels of serotonin in their brains."

From this article with references:

https://www.bbc.com/future/article/20200108-the-medications-that-change-who-we-are

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0124451

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005588/

https://bio.biologists.org/content/7/12/bio030981 Maqdisi (talk) 13:24, 29 March 2023 (UTC)

And you won't. The Pig Farmer has paid for this particular entry. 109.145.66.215 (talk) 23:56, 23 September 2023 (UTC)