Talk:Selenium in biology

	This article is within the scope of WikiProject Molecular Biology, a collaborative effort to improve the coverage of Molecular Biology on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.Molecular BiologyWikipedia:WikiProject Molecular BiologyTemplate:WikiProject Molecular BiologyMolecular Biology articles
???	This article has not yet received a rating on the importance scale.
	This article is supported by the Molecular and Cell Biology task force (assessed as Low-importance).

Food and drink Low‑importance

This article is within the scope of WikiProject Food and drink, a collaborative effort to improve the coverage of food and drink related articles on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.Food and drinkWikipedia:WikiProject Food and drinkTemplate:WikiProject Food and drinkFood and drink articles

Low

This article has been rated as Low-importance on the project's importance scale.

Food and Drink task list:

To edit this page, select here

Here are some tasks you can do for WikiProject Food and drink:

Help bring these Top Importance articles currently B Status or below up to GA status: Agaricus bisporus (i.e. mushroom), Beef, Bread, Curry, Drink, Food, Ham and eggs, Soy sauce, Sushi, Yogurt
Bring these Top Importance articles currently at GA status up to FA status: Beer, French cuisine, Sugar
Bring these High Importance articles currently at GA status up to FA status: Apple, Burger King, Fish
Participate in project-related deletion discussions.
Delete unrelated trivia sections found in articles. Please review WP:Trivia and WP:Handling trivia to learn how to do this.
Add the {{WikiProject Food and drink}} project banner to food and drink related articles and content to help bring them to the attention of members. For a complete list of banners for WikiProject Food and drink and its child projects, select here.
Provide photographs and images for Category:Wikipedia requested images of food
Consider joining this project's Assessment task force. List any project ideas in this section

Note: These lists are transcluded from the project's tasks pages.

Medicine: Toxicology / Genetics Low‑importance

	Medicine portal This article is within the scope of WikiProject Medicine, which recommends that medicine-related articles follow the Manual of Style for medicine-related articles and that biomedical information in any article use high-quality medical sources. Please visit the project page for details or ask questions at Wikipedia talk:WikiProject Medicine.MedicineWikipedia:WikiProject MedicineTemplate:WikiProject Medicinemedicine articles
Low	This article has been rated as Low-importance on the project's importance scale.
	This article is supported by the Toxicology task force (assessed as Low-importance).
	This article is supported by the Medical genetics task force (assessed as Low-importance).

Elements Low‑importance

	Chemistry portal This article is supported by WikiProject Elements, which gives a central approach to the chemical elements and their isotopes on Wikipedia. Please participate by editing this article, or visit the project page for more details.ElementsWikipedia:WikiProject ElementsTemplate:WikiProject Elementschemical elements articles
Low	This article has been rated as Low-importance on the importance scale.

Dietary Supplements Mid‑importance

	Selenium in biology is part of WikiProject Dietary Supplements, a collaborative attempt at improving the coverage of topics related to dietary supplements. If you would like to participate, you can choose to edit this article, or visit the project page for more information.Dietary SupplementsWikipedia:WikiProject Dietary SupplementsTemplate:WikiProject Dietary SupplementsDietary supplement articles
Mid	This article has been rated as Mid-importance on the project's importance scale.

Reason for this article

Most element articles that end up with a bloated biology section end up having a separate health or medical article, such as Copper in health, Magnesium in biology and so on. This bio-bloat has happened to the main selenium article.

I intend to put most of the long health controversy stuff HERE, but leave a short summary behind. Much of the other bio stuff is short and can be duplicated here, with much less shortening in the main element article selenium. Basically, you can look at copper, magnesium, and the other major dietary mineral articles that interface with chemical element articles to see what I intend. S B H arris 19:41, 27 May 2012 (UTC)[reply]

Need suggestions for alternative title for subheading "Controversial health effects"

"Controversial" might not be the best word for the subheading about possible health effects. A more neutral word indicating uncertainty might be more appropriate. "Controversial" suggests antagonism and possibly "junk science," which is not necessarily the case if the purported health effects are suggested or indicated by study or theory, but not fully proven. Unless someone offers a better suggestion, I propose changing the subheading to "Possible health effects". Tetsuo (talk) 05:29, 25 July 2012 (UTC)[reply]

Selenium in TB

I don't think removing the information regarding seleno-amino acid (i.e. se-methylselenocysteine) anti-mycobacterial activity and corresponding reference is appropriate.

I am first author on the antimicrobial agents and chemotherapy publication reference for this fact of in-vitro activity of a very interesting selenium pharmacophore toward mycobacteria. This is peer reviewed primary research in a prestigious international microbiology journal. I have a PhD in the subject of anti-mycobacterial drug development, therefore I believe the inclusion of this mention of activity is relevant and disagree that it is poorly sourced.

Additionally, whilst literature evidence including several large clinical trials is collectively inconclusive regarding selenium supplementation effects toward active TB outcomes, citing an article that claims no effect does not overrule the other articles that demonstrate statistically significant improved outcomes. Although I did not author that particular section, as an expert in the field I suggest both sides should be mentioned. Don't get me wrong, I am strongly against unsubstantiated crackpot supplement science but there is sufficient evidence for selenium supplementation influencing TB outcomes (particularly HIV-TB coinfection) to warrant mention, even if the only effect is alleviation of a selenium insufficiency that commonly occurs in active infection. — Preceding unsigned comment added by 118.93.209.69 (talk) 06:36, 3 October 2014 (UTC)[reply]

What secondary sources do you have in mind that we could be using? Alexbrn ^{talk|contribs|COI} 06:40, 3 October 2014 (UTC)[reply]

No reviews or meta-analysis regarding seleno-amino acid antimycobacterial activity im afraid, but further primary research publications:

Amso, Z., Miller, C., O'Toole R, & Sarojini, V. (2012). Design, synthesis and analysis of anti-tuberculosis peptides. JOURNAL OF PEPTIDE SCIENCE, 18, S33-S33. http://books.google.co.nz/books/about/Seleno_amino_Acids_a_Novel_Class_of_Anti.html?id=xyD8nQEACAAJ&redir_esc=y although I am not sure if a thesis is an acceptable reference. It just feels wrong.

Regarding selenium supplementation and TB:

Shor-Posner, G. et al. Impact of selenium status on the pathogenesis of mycobacterial disease in HIV-1-infected drug users during the era of highly active antiretroviral therapy. J Acquir Immune Defic Syndr 29, 169-73 (2002).

Kassu, A. et al. Alterations in serum levels of trace elements in tuberculosis and HIV infections. European Journal of Clinical Nutrition 60, 580-586 (2006).

Seyedrezazadeh, Ensiyeh, et al. "Vitamin E-selenium supplement and clinical responses of active pulmonary tuberculosis." Tanaffos (2006).

Seyedrezazadeh, Ensiyeh, et al. "Effect of vitamin E and selenium supplementation on oxidative stress status in pulmonary tuberculosis patients." Respirology 13.2 (2008): 294-298.

Shall I take another crack at this section based on the above? — Preceding unsigned comment added by 118.93.209.69 (talk) 09:47, 3 October 2014 (UTC)[reply]

No, we shouldn't use primary sources, especially for biomedical content, and extra-especially when they "complicate" the view as expressed in a strong secondary; in this case a Cochrane review, about the strongest source there can be, gives us the accepted knowledge on this topic as it stands. Wikipedia is an encyclopedia not a research bulletin. Alexbrn ^{talk|contribs|COI} 10:11, 3 October 2014 (UTC)[reply]

From your edit, have you read the Cochrane review? even the abstract? if you did then you are either out of your field of expertise or are deliberately misconstruing information. The same applies for selenium and cancer that I see you also edited. Inconclusive meta analysis does not equal no evidence, and in my opinion if peer reviewed strong in-vitro or other preclinical data exists then it deserves mention for what it is where relevant.

Its not a research bulletin but this certainly falls under selenium in biology and is relevant to health and tuberculosis. The information might be useful to someone so why not disseminate a simple sentence of information. I suspect you have a personal bias here and I note you have a history of this kind of unreasonable one sided editing behaviour. Disappointing, lets have this mediated. — Preceding unsigned comment added by 118.93.209.69 (talk) 13:48, 3 October 2014 (UTC)[reply]

If anyone here is an author or colleague of an author, they probably should not add content. If they feel compelled to comment, do so on this Talk page AFTER registering. Otherwise the edits represent a serious conflict of interest. Dont know why I even need to say this. --Smokefoot (talk) 13:51, 3 October 2014 (UTC)[reply]

From the authors' conclusion of the Cochrane review: "There is currently no reliable evidence that routinely supplementing at or above recommended daily amounts has clinical benefits." No more need be said (granted we could qualify our "no evidence" as "no good evidence"). Our biomedical sourcing guidelines tell us how we should be choosing and using sources here. If there are better sources than Cochrane, then this can be revisited. Alexbrn ^{talk|contribs|COI} 13:57, 3 October 2014 (UTC)[reply]

Dietary Reference Intake

Added section to article on Dietary Reference Intakes (EAR, RDA and UL) for selenium, also mention that European Food Safety Authority set its UL lower than the US, and that the 100% Daily Value for labeling purposes is being decreased from 70 to 55 micrograms, effective 2018. Most 100% DVs now align with the highest RDA (not counting pregnancy or lactation).

Changed section title to Dietary recommendations because Dietary Reference Intakes is used only in U.S. and Canada; added European information, with citations.David notMD (talk) 00:36, 3 September 2017 (UTC)[reply]

Talk:Selenium in biology

Reason for this article

Need suggestions for alternative title for subheading "Controversial health effects"

Selenium in TB

Dietary Reference Intake

Navigation menu

Search