Talk:Mycosis fungoides

User :

Bard , perche la luce del sole, in particolare gli ultravioletti UVB inducono l'apoptosi dei linfociti T tumorali della mycosis fungoides presenti nella pelle ?

Bard di Google :

La luce del sole, in particolare gli ultravioletti UVB, inducono l'apoptosi dei linfociti T tumorali della mycosis fungoides presenti nella pelle attraverso diversi meccanismi.

Uno dei meccanismi è l'induzione di danni al DNA dei linfociti T tumorali. Gli UVB possono danneggiare il DNA in diversi modi, tra cui la formazione di dimeri di timina, la depurinazione e la deaminazione delle basi. Questi danni al DNA possono portare all'induzione dell'apoptosi dei linfociti T tumorali.

Un altro meccanismo è l'induzione di un'infiammazione locale. Gli UVB possono attivare le cellule dendritiche della pelle, che rilasciano citochine pro-infiammatorie. Queste citochine possono indurre l'apoptosi dei linfociti T tumorali.

Infine, gli UVB possono indurre la produzione di molecole anti-cancro. Ad esempio, gli UVB possono indurre la produzione di interleuchina-22, che è una molecola che può uccidere i linfociti T tumorali.

I meccanismi specifici coinvolti nell'apoptosi dei linfociti T tumorali della mycosis fungoides indotta dai raggi UVB non sono ancora del tutto chiari. Tuttavia, è probabile che diversi meccanismi agiscano in sinergia per indurre questo effetto.

I raggi UVB sono stati utilizzati per il trattamento della mycosis fungoides per molti anni. Sono un trattamento efficace per la malattia in stadio iniziale, ma possono causare effetti collaterali, come scottature solari e iperpigmentazione.

In futuro, è probabile che gli studi sulle basi molecolari dell'apoptosi dei linfociti T tumorali della mycosis fungoides indotta dai raggi UVB portino allo sviluppo di nuovi trattamenti più efficaci e con meno effetti collaterali.

User :

Bravo. Spiegami un altra cosa sempre in relazione alla precedente risposta.

Perché l'assunzione di olio di cartamo molto ricco di omega 6 favorisce la remissione delle macchie di micosi fungoides cioè la morte delle cellule linfociti T tumorali, specie se ci prendi subito insieme il sole. Le due cose interagiscono ?

Bard di Google:

L'olio di cartamo è ricco di acidi grassi omega-6, che sono un tipo di grassi insaturi. Gli acidi grassi omega-6 hanno dimostrato di avere un effetto anti-infiammatorio e anti-tumorale.

Nella mycosis fungoides, i linfociti T tumorali si accumulano nella pelle e causano infiammazione. L'infiammazione può contribuire alla crescita e alla diffusione delle cellule tumorali.

L'assunzione di olio di cartamo può aiutare a ridurre l'infiammazione nella mycosis fungoides. Questo può contribuire alla morte delle cellule linfociti T tumorali e alla remissione della malattia.

L'esposizione ai raggi UVB può anche aiutare a ridurre l'infiammazione nella mycosis fungoides. Inoltre, i raggi UVB possono indurre la produzione di molecole anti-cancro, che possono contribuire alla morte delle cellule linfociti T tumorali.

L'olio di cartamo e i raggi UVB possono quindi interagire per aumentare l'effetto anti-infiammatorio e anti-tumorale.

Ecco alcuni meccanismi specifici attraverso i quali l'olio di cartamo e i raggi UVB possono interagire per favorire la remissione della mycosis fungoides:

Gli acidi grassi omega-6 possono aiutare a proteggere le cellule della pelle dai danni dei raggi UVB. Gli acidi grassi omega-6 possono aiutare a stimolare la produzione di molecole anti-infiammatorie, come l'interleuchina-10. I raggi UVB possono aiutare a promuovere il metabolismo degli acidi grassi omega-6, che può aumentare il loro effetto anti-infiammatorio. È importante notare che questi meccanismi non sono ancora stati completamente chiariti. Tuttavia, gli studi suggeriscono che l'olio di cartamo e i raggi UVB possono avere un effetto sinergico per migliorare la prognosi della mycosis fungoides.

È importante consultare un medico prima di iniziare a utilizzare l'olio di cartamo per la mycosis fungoides. — Preceding unsigned comment added by 151.38.103.242 (talk) 21:12, 2 September 2023 (UTC)

note

Anyone can add how fatal this is? Kortsleting (talk) 13:17, 16 February 2016 (UTC)

Somebody did that in January 2018. Thanks to this editor! Linuxo (talk) 08:14, 2 June 2018 (UTC)

Pautrier's microabscesses redirects here

Pautrier's microabscesses redirects here (eg from Sézary disease) but it does not seem to be even mentioned. - Rod57 (talk) 03:27, 30 November 2017 (UTC)

I've edited the diagnosis chapter with criteria on the skin biopsy. There's a little part about "Pautrier microabcesses" inside. Hope it helps. Linuxo (talk) 08:12, 2 June 2018 (UTC)

Bland text cut from Treatments section

I cut the following as it didnt seem specific to MF (and had no source/ref).

Selection of treatments typically depends on patient preference and access to therapies, as well as recommendations by physicians, the stage of the disease, established resistance to prior therapies, allergies of the patient, clinical evidence of a positive benefit:risk ratio, and so on.

If treatment is successful the disease can go into a non-progressing state with clinically clear examination and various tests. This is called remission; it can last indefinitely. Treatments may also cause disease not to progress, while still present, and this is called stable disease; it may last indefinitely but is a more serious situation. Disease may also progress, to involve nodes, blood and internal organs, or transform into a higher-grade lymphoma. The disease is incurable, but many patients experience prolonged periods of disease-control. Quality of life is a major objective, in addition to cure, and maximizing periods of remission or stable disease, while minimizing treatments and toxicities, are two central concerns in clinical care.

- Rod57 (talk) 04:15, 30 November 2017 (UTC)

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Queen's University Student Editing Initiative

Hello, we are a group of medical students (group 7) from Queen’s University. We are working to improve this article over the next month and will posting our planned changes on this talk page. We look forward to working with the existing Wikipedia medical editing community to improve this article and share evidence. We welcome feedback and suggestions as we learn to edit. Thank you. Jsala016 (talk) 20:16, 23 November 2020 (UTC)

1. We propose to insert the following content into the Mycosis fungoides#Signs and symptoms section: "After a few years, patches can develop into solid skin tumours that can develop in any region of the body, including the face and head regions. Pruritus (itching) could become associated with solid skin tumours at this stage."

The proposed changes provide additional details regarding the timeline of the progression of the condition and a clear description of which areas in the body might be affected by tumours. This information is supported by a recent Cochrane review that conforms with the WP:MEDRS guideline. Therefore, we propose to remove the information shared below (The later stages involve the patches evolving into plaques distributed over the entire body. The advanced stage of mycosis fungoides is characterized by generalized erythroderma, with severe pruritus and scaling.) Jsala016 (talk) 01:44, 24 November 2020 (UTC)

Note: Multiple use of the same reference- tech tip. When you add your references while editing, you can see the options "automatic... Manual... Re-use". The first time you add the citation (if it is not already used in an article, click "automatic" and add your PMID, DOI, or website, then click "generate" to fill the template. The second time you want to use the same citation in an article, click "reusue" and search for your citation in the list. This adds in the a,b,c versus duplicating the citation in the list. If possible, practice this in your sandbox before editing live on Monday.JenOttawa (talk) 04:40, 5 December 2020 (UTC)

References

2. We propose that the first sentence of the Signs and Symptoms section be changed to: “The symptoms of mycosis fungoides are categorized into three clinical stages: the patch stage, the plaque stage, and the tumour stage.” Since patches, plaques, and tumours are lesions, it would be clearer to define the clinical stages outright.

References

3. We propose adding a statement “The patch stage is defined by flat, reddish patches of varying sizes that may have a wrinkled appearance. They can also look yellowish in people with darker skin.”

We propose replacing the sentence “These lesions prefer the buttock region” with the sentence “Lesions often first develop on the trunk of the body, in places that are rarely exposed to the sun, such as the buttocks.” The initial patches that present can be found on the buttocks, but they are also often found on the trunk of the body in general. PlatypusBear (talk • contribs) 21:49, 30 November 2020 (UTC)

References

4. We propose to edit the following sentence in the Diagnosis subsection: “Diagnosis is sometimes difficult because the early phases of the disease often resemble inflammatory dermatoses (such as eczema, psoriasis, lichenoid dermatoses including lichen planus, vitiligo, and chronic cutaneous lupus erythematosus), as well as other cutaneous lymphomas."

These sentence edit adds information concerning other common differential diagnoses of Mycosis fungoides such as lupus and lichen planus; it specifically outlines common symptoms found in both MF and these conditions. Currently on the wikipedia page, there is only one sentence referencing differential diagnoses of MF, touching only on eczema and psoriasis. Muchacha7 (talk) 23:04, 30 November 2020 (UTC)

References

5. We propose to insert the following content into the Diagnosis#Signs and Symptoms section:

If mycosis fungoides develops to meet the criteria for Sézary syndrome, it is referred to as leukemic mycosis fungoides, Sézary syndrome preceded by mycosis fungoides, or secondary mycosis fungoides. People with this stage of the condition usually present with the red, inflamed lesions characteristic of mycosis fungoides, as well as leukemic disease.

This addition will help contextualize Sézary syndrome in the context of mycosis fungoides development. Adding this information will help explain the progression of the disease to the reader. Different terms used to refer to this syndrome when it is developed in the context of mycosis fungoides were added in order to clarify that these different clinical terms are all referring to the same thing. I welcome any feedback you may have! THank you for the time and effort you put into improving Wikipedia. Mitochondriac22 (talk) 23:16, 30 November 2020 (UTC)

References

6. We propose adding the following sentences into the Mycosis fungoides#Signs and symptoms section:

“The plaque stage follows the patch stage of mycosis fungoides. It is characterized by the presence of raised lesions that appear reddish-brown; in darker skin tones, plaques may have a greyish or silver appearance. Both patch and plaque stages are considered early-stage mycosis fungoides.”

The proposed changes provide more detailed information about the plaque stage of mycosis fungoides. This information may help to differentiate the signs and symptoms of patch and plaque stages. As detailed above, this information will replace the current sentence: “The later stages involve the patches evolving into plaques distributed over the entire body. The advanced stage of mycosis fungoides is characterized by generalized erythroderma, with severe pruritus and scaling”.

Thank you! Jk2jk (talk) 02:28, 1 December 2020 (UTC)

7. We propose adding the following sentences into the Mycosis fungoides#Diagnosis section:

Most patients with Mycosis Fungoides have early stage disease (Stage IA-IIA) at the time of their initial diagnosis. These patients with early stage disease that is primarily confined to the skin have a favorable prognosis. Patients with advanced stage (Stage IIB-IVB) are often refractory to treatment and have an unfavorable prognosis. Treatment of patients with advanced stage disease is designed to reduce tumor burden, delay disease progression, and preserve quality of life.

Thank youJamesjonathan7 (talk) 04:08, 3 December 2020 (UTC)

References

December 2020: Please be bold and make your proposed edits

Your proposals are sound. Please feel free to BE BOLD and implement them in the article. And thank you.--Quisqualis (talk) 16:37, 7 December 2020 (UTC)

Queen's University Student Editing Initiative 2021

Hello, we are a group of medical student’s from Queen’s University. We are working to improve this article over the next month and will posting our planned changes on this talk page. We look forward to working with the existing Wikipedia medical editing community to improve this article and share evidence. We welcome feedback and suggestions as we learn to edit. Thank you. SGL14EH (talk) 20:07, 15 November 2021 (UTC)

Improvement 1

We propose to introduce the relationship between SS and MF earlier to improve clarity: "People with mycosis fungoides can also develop Sézary syndrome (SS). SS is a rare leukemic variant where cancerous lymphocytes found in mycosis fungoides are also found in the blood (leukemic disease). It is referred to as leukemic mycosis fungoides, Sézary syndrome preceded by mycosis fungoides, or secondary mycosis fungoides. However, not all forms of Sézary syndrome are an advanced form of mycosis fungoides." Tnarang

Thank you for sharing this suggestion. Should we include a wikilink for Sézary syndrome?JenOttawa (talk) 00:48, 23 November 2021 (UTC)

Improvement 2

We propose changing the following in the Signs and Symptoms section. Deleting the first sentence on Pruritus and adding the following sentence just previous to the discussion of Sezary Symptoms. "Itching (Pruritus) is the most commonly reported symptom of people experiencing Mycosis Fungoides with up to 88% of people reporting varying intensities of pruritus that typically worsens as the disease progresses. Those that experience intense pruritus commonly indicate that it negatively affects their quality of life emotionally, functionally and physically. Oheid25 (talk) 21:22, 17 November 2021 (UTC)

Looks good. Super minor edit- remove the space between the citation and the punctuation. JenOttawa (talk) 01:00, 23 November 2021 (UTC)

Improvement 3

We propose the following change after the second sentence in the Signs and Symptoms section "The progression of MF is initially slower and later accelerates. The overall average disease progresssion in people with mycosis fungoides is approximately 12 years. There is no controversy in this article." Blairrachel123 comment added 20:18, 16 November 2021 (UTC)

Feedback: Try to remove the use of "patients"- i.e., overall average disease progresssion in people with mycosis fungoides is approx...". If there are page #s from you text book about where you found this information please include as well. Great edit! JenOttawa (talk) 01:02, 23 November 2021 (UTC)

Improvement 4

We propose the following change after the word "buttocks" in the Signs & Symptoms section: These lesions can start as insignificant patches and may remain undiagnosed for up to a decade [1]. Hypopigmented (when the skin is lighter than normal) lesions are less common but can be found in children, adolescents and/or dark-skinned individuals [2].

Feedback: This edit looks good. Can you try to add the citation using the 'cite tool' as we practiced in class in your sandbox? Please reach out if you are having trouble. The talk page is not set up for the visual editor tool so it is normal that some people had trouble here.I am happy to help in our final session next week. JenOttawa (talk) 01:04, 23 November 2021 (UTC)

Improvement 5

We propose adding additional information on treatment of relapsed or refractory MF, replacing the last sentence of the Treatment section with "Systemic treatments of mycosis fungoides often lead to resistance; as such, additional treatment options are often necessary in advanced disease. Mogamulizumab is a CCR4 monoclonal antibody which has been shown to improve progression-free survival. It was approved by the US FDA in 2018 for use in people with relapsed or refractory mycosis fungoides or Sézary disease." SGL14EH (talk) 20:55, 17 November 2021 (UTC)

Feedback: Please note that the citation goes immediately after the punctuation and not before. Just a picky edit, your improvement looks great.JenOttawa (talk) 01:06, 23 November 2021 (UTC)

Improvement 6

We propose adding the following information to the beginning of the "Treatments" section: "The most commonly recommended first-line treatment for mycosis fungoides is psoralen plus ultraviolet A (PUVA therapy). PUVA is a photochemotherapy that involves topical or oral administration of the photosensitizing drug psoralen followed by skin exposure to ultraviolet radiation. Although other treatments have been used in combination with PUVA, there is a lack of evidence to support that these combination therapies are effective. ". We also propose citing "interferons" as an example of biological treatments rather than a systemic treatment. SGL14 RS (talk) 02:24, 18 November 2021 (UTC)

Feedback: Are there any wikilinks that would be appropriate to add here? Looks good!JenOttawa (talk) 01:08, 23 November 2021 (UTC)

Improvement 7

We propose adding the following information to the "Treatments" section: "Treatment for adults and children with Mycosis Fungoides often differs because of the safety profiles of modalities. Narrowband UV-B is commonly considered for children, as opposed to Psoralen with UV-A, mechlorethamine hydrochloride, and oral bexarotene, which is often used in adults" ." Nanjij (talk) 13:50, 19 November 2021 (UTC)

Great work preparing these. ould UV-B be wikilinked? I don't think you need to use capitals on on the drug names or the condition name when it is in a sentence like this. Nice systematic review! Super minor comment: note your placement of the citation (move it to immediately after the punctuation, no space).JenOttawa (talk) 01:11, 23 November 2021 (UTC)

Improvement 8

We propose adding the following information to the "Prognosis" section: "In children, a significant delay in correct diagnosis from the onset of lesions is associated with poorer outcomes and poorer overall survival rates ."Nqmed (talk) 13:49, 19 November 2021 (UTC)

Good use of this systematic review. This edit looks good. Super minor comment: note your placement of the citation (move it to immediately after the punctuation, no space).JenOttawa (talk) 01:12, 23 November 2021 (UTC)

Improvement 9

We propose adding a sentence directly prior to “The patch stage is defined by flat, reddish patches of varying sizes that may have a wrinkled…” in the "Signs and Symptoms" section: The patch stage can be subdivided into stage IA and IB, defined by the amount of surface area the patches cover (Stage IA, covering less than 10% of the skin’s surface area and Stage IB greater than 10% of the skin’s surface area).

Looks good. Super minor comment: note your placement of the citation (move it to immediately after the punctuation, no space).JenOttawa (talk) 01:13, 23 November 2021 (UTC)

Improvement 10

We propose adding the following sentence "As the patches spread, they can evolve into palpable plaques, known as the plaque stage" after the sentence " they can also look yellowish in people with darker skin" to the "Signs and Symptoms" section.

This looks good. Super minor comment: note your placement of the citation (move it to immediately after the punctuation, no space).JenOttawa (talk) 01:14, 23 November 2021 (UTC)

Improvement 11

This statement should be added under “Diagnosis” on the Mycosis fungoides wiki page: Childhood Mycosis fungoides (MF) makes up 0.5% to 7.0% of cases . Although data on childhood MF is limited, a 2021 systematic review observed that there is a significant delay in the diagnosis of childhood MF which may negatively affect a child’s prognosis. Notably, most pediatric persons with MF present with early-stage disease.18jsj3 (talk) 13:59, 18 November 2021 (UTC)

Nice work here. Super minor comment: note your placement of the citation (move it to immediately after the punctuation, no space). When sharing evidence from a systematic review, it is usually not necessary to state that your evidence came from a systematic review. There are a few cases where this is helpful though (See breast cancer screening or flu shot wiki articles, for example).

Note: Please re-use your citation after the last sentence. Did I interpret your evidence correctly? Please adjust if I made a mistake! JenOttawa (talk) 01:18, 23 November 2021 (UTC)

Improvement 12

There should be a new subheader for “Histological Features” in the “Diagnosis” section, and the disease criteria should be reworded as follows:

Histology Features

The criteria for the disease are established on the skin biopsy by the presence of the following[10]: The superficial papillary dermis is infiltrated by a band of cancer cells (Vaidya & Badri, 2021) Epidermotropism during the early stages, characterized by dense infiltrates of cancer cells clustered in the epidermis (Vaidya & Badri, 2021) Presence of atypical T-cells with cerebriform nuclei in the dermal and epidermal infiltrates Pautrier's microabcesses, aggregates of four or more atypical lymphocytes arranged in the epidermis.[11] Pautrier microabcesses are characteristic of mycosis fungoides but are generally absent. Whynoteditawiki (talk) 23:36, 18 November 2021 (UTC)

Thanks for this suggestion. It looks good. Please practice inserting your references with the citation tool. I realize it is different here on the talk page without the visual editor. If you need help while editing live next week please don't hesitate to ask!JenOttawa (talk) 01:22, 23 November 2021 (UTC)

Improvement 13

This statement will be added at the end of the “Histology” subsection in the “Diagnosis” section. “Early phases of MF are difficult to diagnose because its histopathological hallmark features (i.e. Pautrier's microabscesses and epidermotropism) are often absent in early MF. Furthermore, long periods of treatment before a biopsy is performed can cause the specimen to have “non-specific” histopathological features, making it difficult to distinguish from other inflammatory dermatoses.” Kim779 (talk) 04:52, 20 November 2021 (UTC)

Looks great. Are there any terms that you can add wikilinks to here? JenOttawa (talk) 01:23, 23 November 2021 (UTC)

Improvement 14

We propose that this statement should be added to “Diagnosis” section under the paragraph regarding Pautrier’s microabscesses: “T-lymphocyte clonality testing can be undertaken to identify whether cancer cells originateed from a single mutated cell. This can be done through special stains (e.g., immunohistochemistry) and genetic testing (e.g., polymerase chain reaction)." 99kiru12 (talk) 14:30, 18 November 2021 (UTC)

Good work preparing this.JenOttawa (talk) 01:24, 23 November 2021 (UTC)

Improvement 15

This paragraph should be added to the “Staging” section: The histopathology of Mycosis Fungoides can be divided into three stages: The Patch stage, The Plaque stage and The Tumour stage . In early patch stages it can be difficult to diagnose, however as patches become more established an atypical lymphocytic proliferation (lymphocytic infiltrate) can be seen. This stage also can mimic other disorders such as eczema making further testing necessary to make a diagnosis. In the plaque stage, the epidermis shows an overgrowth (acanthosis) in addition to more cell movement towards the epidermis (epidermotropism). In the tumour stage, tumours will begin to form making a denser infiltrate there will be a diminished number of T lymphocytes, which are an essential part of our immune system. Farzanansari10 (talk) 14:07, 18 November 2021 (UTC)

Feedback: This looks good to me. I don't think that capitals are necessary on the names of the stages: The Patch stage, The Plaque stage and The Tumour stage. Are there are any wikilinks that can be added to help define text and link to other articles. JenOttawa (talk) 14:37, 23 November 2021 (UTC)

Improvement 16

Current sentence under “Diagnosis”: Several biopsies are recommended, to be more certain of the diagnosis. Change: A biopsy, or several biopsies, is insufficient to diagnose mycosis fungiodes. Instead, a complete diagnosis requires a combination of clinical and histological study.

Feedback: This looks good. Can you please share the citation that you propose to use to support this sentence?JenOttawa (talk) 14:39, 23 November 2021 (UTC)

Improvement 17

The following should be added under the "Treatment" subheading: Treatments are often used in combination and depend on the staging of mycosis fungoides. Treatment of stage I and stage II often includes radiation therapy, immunotherapy, topical chemotherapy, systemic chemotherapy or targeted therapy. Stage III and stage IV mycosis fungoides offer the addition of extracorporeal photochemotherapy. Lastly recurrent mycosis fungoides can also be treated with high-dose chemotherapy with a stem cell transplant as well as all treatment options listed above. Weersinkedit (talk) 17:06, 18 November 2021 (UTC)

Feedback: Your citation looks good. Please watch the use of capitals (keep it consistent). We usually do not use capitals on medical terms in the middle of the sentence (e.g.- chemotherapy), you can link it without the capital. Only one more picky suggestion- please ensure that the citation is placed behind the punctuation like this.¹ JenOttawa (talk) 14:42, 23 November 2021 (UTC)

Improvement 18

I wish to add the following survival rates for the different stages of this disease Original: Most patients with Mycosis Fungoides have early-stage disease (Stage IA-IIA) at the time of their initial diagnosis.[13] These patients with early stage disease that is primarily confined to the skin have a favorable prognosis.[13] Patients with advanced stage (Stage IIB-IVB) are often refractory to treatment and have an unfavorable prognosis.[13] Treatment of patients with advanced stage disease is designed to reduce tumor burden, delay disease progression, and preserve quality of life.[13] Edits: Most patients with Mycosis Fungoides have early-stage disease (Stage IA-IIA) at the time of their initial diagnosis.[13] These patients with early stage disease that is primarily confined to the skin have a favorable prognosis, with a 5-year survival rate of 85.8% for Stage IB.[13, 14] Patients with advanced stage (Stage IIB-IVB) are often refractory to treatment and have an unfavorable prognosis, with a 5-year survival rate of 62.2% for Stage IIB and as low as 23.3% in Stage IVB, the further stage.[13,14] Treatment of patients with advanced stage disease is designed to reduce tumor burden, delay disease progression, and preserve quality of life.[13] Reference: [14] Mourad A, Gniadecki R. Overall Survival in Mycosis Fungoides: A Systematic Review and Meta-Analysis. J Invest Dermatol. 2020 Feb;140(2):495-497.e5. doi: 10.1016/j.jid.2019.07.712. Epub 2019 Aug 26. PMID: 31465745. Dannythekey (talk) 05:15, 19 November 2021 (UTC)

Feedback: On Wikipedia we try to avoid using "patients"- "Most people with mycosis fungoides have early-stage..." and "for people with advanced stage disease", for example. Please also ensure that you are prepared to add your citations with the 'cite tool' on Wikipedia as we learned in class. It is harder to practice this on the talk page as it does not use the visual editor (as you likely noticed). Please practice in your sandbox and reach out next week if you need help making the edit live on Wikipedia.JenOttawa (talk) 14:50, 23 November 2021 (UTC)

Improvement 19

We propose combining the first two sentences of the Epidemiology section about disease incidence/frequency by age and adding an additional sentence about disease pattern by sex and ethnic group, as follows: “It is rare for Mycosis Fungoides to appear before age 20; the average age of onset is between 45 and 55 years of age for people with patch and plaque disease only, but is over 60 for people who present with tumours, erythroderma (red skin) or a leukemic form (the Sézary syndrome). Mycosis Fungoides is more common in males than in females with the majority of people living with the disease being of Caucasian ethnicity.” --Jzucker14 (talk) 00:35, 20 November 2021 (UTC)

Feedback: This looks good. Good use of your reference. No need to capitolize mycosis fungosis mid sentence. I am not certain if caucasian needs to be capitolized. JenOttawa (talk) 14:52, 23 November 2021 (UTC)

Improvement 20

I will be making the following edit: Original: “The incidence of mycosis fungoides was seen to be increasing till the year 2000 in the United States,[20] thought to be due to improvements in diagnostics.”

Edits: “The incidence of mycosis fungoides was seen to be increasing till the year 2000 in the United States,[20] thought to be due to improvements in diagnostics. This contrasts to a reported increase in incidence in the Netherlands between 2000 and 2020, suggesting regional trends.[21] Reference: Ottevanger, R. O. S. A. N. N. E., de Bruin, D. T., Willemze, R., Jansen, P. M., Bekkenk, M. W., de Haas, E. R. M., ... & Quint, K. D. (2021). Incidence of mycosis fungoides and Sézary syndrome in the Netherlands between 2000 and 2020. The British journal of dermatology, 185(2), 434. ImranMSyed (talk • contribs) 15:13, 19 November 2021 (UTC)

Feedback: Please practice adding your citation using the citation tool as we did in class. You can practice in your sandbox and reach out in class if you need further assistance. Here is an example of what it should look like: “The incidence of mycosis fungoides was seen to be increasing till the year 2000 in the United States,[20] thought to be due to improvements in diagnostics. This contrasts to a reported increase in incidence in the Netherlands between 2000 and 2020, suggesting regional trends. JenOttawa (talk) 14:56, 23 November 2021 (UTC)

Improvement 21

We propose to insert the following content into the "Prognosis" section:

“In mycosis fungoides cases where affected lymphocytes grow with disease progression (large cell transformation), presence of the transmembrane receptor CD30 in affected cells is associated with improved survival.”

Endothelium (talk) 23:22, 19 November 2021 (UTC)

Feedback: This looks good. Are there any wikilinks that would be appropriate to add here? JenOttawa (talk) 14:57, 23 November 2021 (UTC)

Improvement 22

We propose the following changes for the "Cause" section:

Mycosis fungoides is caused by a proliferation of malignant T cells which have a preference for localizing to the epidermis (outermost layer of skin). It is hypothesized that genetic and cellular signalling abnormalities are involved in the malignancy and increased proliferation of the cancerous T-cells. ” Llokdew (talk) 01:33, 20 November 2021 (UTC) Thank you to the community for your time and review of our proposed changes. We welcome any feedback or suggestions.

Feedback: This looks good. It is quite technical, however, I realize it is hard to summarize. A few wikilinks (if not already linked earlier in the article) may help. Very minor edit is also to ensure that the citation is located immediately after the punctuation (no space).JenOttawa (talk) 14:59, 23 November 2021 (UTC)

References