Talk:Leber's hereditary optic neuropathy

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Introductory sentence

The opening sentence states: Leber’s hereditary optic neuropathy (LHON) or Leber optic atrophy is a maternally inherited form of acute or subacute loss of central vision that may lead to degeneration of retinal ganglion cells (RGCs) and their axons... Degeneration leads to vision loss, not the other way around. Anyone agree that this should be changed? AED 06:30, 28 July 2005 (UTC)[reply]

vandalism

I removed the section regarding clinical trials in the UK. It may be relevant to the article, but it's still advertising. This user has been told numerous times about vandalism, so see the users page or their other page. If anyone has a good reason to revert it, then revert it. Jay.S 22:12, 14 February 2007 (UTC)[reply]

contradiction in opening paragraph

the part in brackets about 1 in 100000 men passing on mitchondria means that a man could pass on this disease to his offspring it would just be extremely unlikely. Sorry to be such a pedant. Greatunknown1 00:27, 15 November 2007 (UTC)[reply]

Removed reference to paternal inheritance of mtDNA

Paternal inheritance has never been proven to take place in humans. The latest studies have been unable to find a single case, even among those that in the past were thought to have been candidates for this.
Telling people that mitochondrial diseases are sometimes paternally inherited is in this case not just some sort of obscure scientific controversy, but is actually damaging to people who are trying to learn about these diseases. What about a man who has such a condition who reads this, and then is worried that he might pass it on to his children? What if he decides not to have children, or get a vasectomy, based on what he read here?
Archaeogenetics (talk) 01:00, 14 February 2008 (UTC)[reply]


Citation for edit

I added age of onset to Signs and Sx. Here is the citation. The clinical characteristics of pedigrees of Leber's hereditary optic neuropathy with the 11778 mutation. 

Newman NJ; Lott MT; Wallace DC  
Am J Ophthalmol 1991 Jun 15;111(6):750-62.  —Preceding unsigned comment added by 204.86.231.10 (talk) 14:37, 4 June 2008 (UTC)[reply]

cures

I've deleted the section on cures as it didn't reference a specific article (or rather it didn't give a proper bibliographic entry). It seems somewhat reckless to title a section as "cures" when it really doesn't provide much information. —Preceding unsigned comment added by 72.39.239.173 (talk) 03:17, 28 November 2008 (UTC)[reply]

Gene Therapy

Both Gensight and Spark Therapeutics have committed to developing a gene therapy treatment for LHON.

http://www.fiercebiotech.com/press-releases/spark-unveils-vision-having-10-clinical-stage-gene-therapy-programs-2018-in

http://www.gensight-biologics.com/index.php?page=mts

Using a vector and injection into the eye, a gene and mitochondrial targeting sequence are used to transfer the resultant mRNA to the surface of the mitochondria, overcoming the hydrophobicity of the the mtDNA encoded proteins which prevented nuclear expression of these genes in the past. The Gensight approach is now in phase 3 clinical trials.

https://clinicaltrials.gov/ct2/show/NCT02652780?term=Gensight&rank=1 — Preceding unsigned comment added by Jimbrizzy (talk • contribs) 14:47, 3 February 2016 (UTC)[reply]

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External links modified

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