Talk:Hydralazine

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First Aid for Step 1 used as a source

I dunno...for some reason using an exam review book as source seems strange, maybe because it's a secondary/tertiary source already and it's leaves out so many things. -- Bubbachuck (talk) 00:59, 31 March 2009 (UTC)[reply]

Hydralazine as an NO donor

Apart from the web site it's linked to which does not give any source itself, I could not find any evidence in the literature that hydralazine is an NO donor. The closest I found for a mechanism is this paper: Knowles HJ, Tian YM, Mole DR, Harris AL (2004) Novel mechanism of action for hydralazine: induction of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and angiogenesis by inhibition of prolyl hydroxylases. Circ. Res. 95(2):162-9. However, this paper proclaims a mechanism altering protein expression which would not explain if it can cause relaxation of blood vessels in an organ bath (not that I ever investigated, might be an interesting student experiment!). -- 134.225.154.77 (talk) 14:44, 27 April 2009 (UTC)[reply]

The website listed looks like its from some med school class. I couldn't find any review articles after a cursory search, but I didn't invest a lot of effort either. This article, most of the Wiki drug articles actually, need disclaimers. — Preceding unsigned comment added by 63.152.116.59 (talk) 18:19, 8 June 2012 (UTC)[reply]

Hydralazine and it's effect of limiting B6 in the human body would seem to be an important subject that is not addressed.

--75.142.159.240 (talk) 15:35, 6 June 2010 (UTC)[reply]

1949

This ref says it was discovered in 1949.[1] Doc James (talk · contribs · email) 04:44, 3 March 2017 (UTC)[reply]

Easy to get that kind of stuff wrong when something is that old. They provide no ref either. Sources i have been using cite publications and talk about when it was first published. Jytdog (talk) 13:45, 3 March 2017 (UTC)[reply]
We have one book here that says it was patented in 1949[2]. Doc James (talk · contribs · email) 14:40, 3 March 2017 (UTC)[reply]
did you really just actually shoot me a general search result at google books? c'mon doc james.
the ref i brought, this one, has footnote 66 which is the Schroeder ref cited in the body -- Schroeder, NA (January 1952). "The effect of 1-hydrasinophthalasine in hypertension". Circulation. 5 (1): 28–37. PMID 14896450. --which has the free full text pdf and is from 1952 which says: "A new compound, 1-hydrazinophthalazine (C-5968), has been shown by Reubi (1) to cause hemodynamic effects which suggest that it may act as an antihypertensive agent." I couldn't get my hands on any of those refs (the Reubi one is PMID 15402536) The refs are all from 1950. I also found this JAMA paper from 1953 that talks about "first published 3 years ago". That is why I said "first published in 1950". I have found no source that credibly gives a date for the invention. Lots for first published in 1950. Jytdog (talk) 17:28, 3 March 2017 (UTC)[reply]
PMID 13019918 which also full free text available says: The depressor properties of Apresoline were discovered in the course of testing of antimalarial drugs. (6}" and the paper cited there is GROSS, F., DRUEY, J., AND MEIER, R.: A new group of depressor substances with a special type of effect. Experientia 6: 19, 1950. -- I cannot get my hands on that paper either. Jytdog (talk) 17:33, 3 March 2017 (UTC)[reply]
Patented in 1949[3]. Doc James (talk · contribs · email) 00:17, 4 March 2017 (UTC)[reply]
OK, so i looked at both the drugbank entry and the pubchem and the earliest patent cited in them is this one: US2484029. (see the compound in Example 1 on the first page). The patent issued in 1949. It was first filed in December 1945. So with regard to the discovery of the chemical itself, this happened sometime before December 1945. The discovery of the blood-pressure lowering ability of this compounds is also described in the patent (so same two dates). The first publication in the literature of the blood-pressure lowering ability seems to be 1950. Am fine with stating any of those facts. As far as I can see nothing was discovered in 1949, mister. Jytdog (talk) 00:46, 4 March 2017 (UTC)[reply]
Yes have already changed the wording to patented in 1949 from discovered. Doc James (talk · contribs · email) 01:55, 4 March 2017 (UTC)[reply]
all good now. thanks! Jytdog (talk) 01:58, 4 March 2017 (UTC)[reply]
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