Talk:Foam cell

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' ' ' ' 'This is Anderson2013a and I am improving this page for a class project under the supervision of Mr. Travis Bohrer (User:tbohrer74) at Waynesville High School.' ' ' ' ' — Preceding unsigned comment added by Anderson2013a (talk • contribs) 14:14, 14 March 2013 (UTC)

Cells

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Foam cells in cholesterolosis of the gallbladder. H&E stain.Foam cells are cells in an atheroma derived from both macrophages[1] and smooth muscle cells[2] which have accumulated low density lipoproteins, LDLs, by endocytosis. The LDL has crossed the endothelial barrier and has been oxidized by reactive oxygen species produced by the endothelial cells. Foam cells can also be known as fatty like streaks and typically line the intima media of the vasculature.

Foam cells are not dangerous as such, but can become a problem when they accumulate at a particular foci thus creating a necrotic centre of the atherosclerosis. If the fibrous cap that prevents the necrotic centre from spilling into the lumen of a vessel ruptures, a thrombus can form which can lead to emboli occluding smaller vessels. The occlusion of small vessels results in ischemia, and contributes to stroke and myocardial infarction, two of the leading causes of cardiovascular-related death. —Preceding unsigned comment added by 67.52.222.82 (talk) 22:06, 9 February 2009 (UTC)

Precursor cells

The term "phagocytes" was neither introduced nor linked - I corrected to "The oxidized LDL accumulates in the macrophages and other phagocytes, which are then known as foam cells", according to Atherosclerosis#Causes: "The body's immune system responds to the damage to the artery wall caused by oxidized LDL by sending specialized white blood cells (macrophages and T-lymphocytes) to absorb the oxidized-LDL forming specialized foam cells".

This seems to be in contrast to the first sentence of the present lemma: "Foam cells are cells in an atheroma derived from both macrophages and smooth muscle." Could someone check and correct, if necessary? Regards --Jwollbold (talk) 12:52, 3 September 2012 (UTC)

M1 or M2 ?

I wonder if there is a robust updated view about foam cells as M1 or M2 macrophages. I am confused by the differences in published articles: eg. https://pubmed.ncbi.nlm.nih.gov/37059130/ and https://pubmed.ncbi.nlm.nih.gov/37215106/ (M1) vs. https://pubmed.ncbi.nlm.nih.gov/29891687/ (M1/M2) vs. https://pubmed.ncbi.nlm.nih.gov/22356914/ (M2). --Nirts (talk) 17:59, 7 June 2023 (UTC)