Talk:Darbepoetin alfa

Untitled

Moleculer weight = 37 kDa —Preceding unsigned comment added by 125.16.17.1 (talk) 06:34, 10 November 2009 (UTC)

Citation for manufacture using Chinse hamster ovary (CHO) cells can be found here in section 11 of the Aranesp full prescribing information, http://pi.amgen.com/united_states/aranesp/ckd/aranesp_pi_hcp_english.pdf That section also confirms the molecular weight info above.

"11 DESCRIPTION Aranesp (darbepoetin alfa) is an erythropoiesis-stimulating protein that is produced in Chinese hamster ovary (CHO) cells by recombinant DNA technology. Aranesp is a 165-amino acid protein that differs from recombinant human erythropoietin in containing 5 N-linked oligosaccharide chains, whereas recombinant human erythropoietin contains 3 chains. The 2 additional N-glycosylation sites result from amino acid substitutions in the erythropoietin peptide backbone. The approximate molecular weight of darbepoetin alfa is 37,000 daltons." — Preceding unsigned comment added by 68.82.238.149 (talk) 20:30, 4 February 2013 (UTC)

External links modified

Hello fellow Wikipedians,

I have just modified 5 external links on Darbepoetin alfa. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:

• Corrected formatting/usage for http://www.fda.gov/cder/foi/appletter/2001/darbamg091701L.htm
• Added archive https://web.archive.org/web/20061017113846/http://emea.europa.eu/humandocs/PDFs/EPAR/aranesp/129901en1.pdf to http://www.emea.europa.eu/humandocs/PDFs/EPAR/aranesp/129901en1.pdf
• Corrected formatting/usage for http://www.fda.gov/cder/drug/advisory/RHE2007.htm
• Corrected formatting/usage for http://www.fda.gov/cder/drug/InfoSheets/HCP/RHE2007HCP.htm
• Added archive https://web.archive.org/web/20141103190540/http://www.asco.org/quality-guidelines/asco-ash-clinical-practice-guideline-update-use-epoetin-and-darbepoetin-adult to http://www.asco.org/quality-guidelines/asco-ash-clinical-practice-guideline-update-use-epoetin-and-darbepoetin-adult

When you have finished reviewing my changes, please set the checked parameter below to true or failed to let others know (documentation at {{Sourcecheck}}).

This message was posted before February 2018. After February 2018, "External links modified" talk page sections are no longer generated or monitored by InternetArchiveBot. No special action is required regarding these talk page notices, other than regular verification using the archive tool instructions below. Editors have permission to delete these "External links modified" talk page sections if they want to de-clutter talk pages, but see the RfC before doing mass systematic removals. This message is updated dynamically through the template {{source check}} (last update: 18 January 2022).

• If you have discovered URLs which were erroneously considered dead by the bot, you can report them with this tool.
• If you found an error with any archives or the URLs themselves, you can fix them with this tool.

Cheers.—InternetArchiveBot (Report bug) 19:30, 6 December 2016 (UTC)