Talk:Clomifene

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Wiki Education Foundation-supported course assignment

This article was the subject of a Wiki Education Foundation-supported course assignment, between 1 July 2019 and 23 August 2019. Further details are available on the course page. Student editor(s): Vicknguy, Snselim, Msleee, Storm1625.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 17:52, 16 January 2022 (UTC)[reply]

chemical structure

The 3D and 2D chemical structures are inconsistent--the two benzene rings are cis in one and trans in the other. I don't know which is correct, but this seems like a significant issue. 171.66.211.4 (talk) 23:42, 14 November 2017 (UTC)[reply]

You're right, it's inconsistent; yet strangely consistent with the Geometric isomerism of clomifene which is part enclomifene (the cis isomer) and part zuclomifene (the trans isomer). — Preceding unsigned comment added by 47.201.185.190 (talk) 21:35, 19 September 2018 (UTC)[reply]

abuse

Someone inserted this:

Clomifene is commonly used by male anabolic steroid users to bind the estrogen receptors in their bodies, therby blocking the effects of estrogen. It simultaniously restores the bodies natural production of testosterone. It is commonly used as a "recovery drug" and taken toward the end of a steroid cycle.

Without a source this sounds odd. Clomifene works on the pituitary by interrupting the sex hormone-gonadotrope feedback loop. JFW | T@lk 11:39, 11 December 2005 (UTC)[reply]

The information posted is correct. Clomid is also a SERM (selective estrogen receptor modulator), which can prevent the growth of breast tissue in males who use anabolic steroids. Jrkarp 03:53, 15 December 2005 (UTC)[reply]

I know it's as SERM. I wrote this article and the SERM article :-) JFW | T@lk 08:57, 15 December 2005 (UTC)[reply]


Added 2 links and a small section on Side Effects User:Maggieliz 2-23-06


History???

History: Regarding serious birth defects and birth anomalies: See "The Price of Ovulation" by Terrance Mix. — Preceding unsigned comment added by Concerned 23 (talk • contribs) 04:30, 10 October 2011 (UTC)[reply]


I wish someone would say something about clomid's history and apparently, it has just always existed. No one discovered it. Does anyone know anything about it? Anything at all?

I purchaed serophene 100mg at on-line "Canadian Pharmacy" and cost about $300. However the the shipping of the drug packet came to me was from India, and cames with no user instractions or any discription. The back of the drug packet labled as "CLOFI-100" it also has tiny small words says Clomifene Tables IP 100mg. They are lillte dark brown color pills. I searched the information on the Internet, many sites says it is "white" color. Could anyone tell me "what is the color of Colmifene"? Should I trust this drug from this on-line drag store? —Preceding unsigned comment added by 60.230.198.238 (talk) 13:51, 4 April 2010 (UTC)[reply]

I removed your link to the "Canadian Pharmacy" in India. You (unintentionally, I hope) are promoting this illegal pharmacy by including it. In any event, the pills you paid $300 for are not Clomid, and I wouldn't put any drug available ONLY WITH A PRESCRIPTION that I bought online at some "Canadian Pharmacy" that ships from India anywhere near my body. Clomid is a white to pale yellow pill. Might I recommend getting them legally from, say, a doctor? I paid 50 cents each for them with my prescription. Without insurance, they were $25 for ten. Here is the FDA fact sheet on Clomid, which includes a picture. http://www.drugs.com/pro/clomid.html

Misc

In the table, under "legal status", it says "POD". What's that mean? I cannot find anything in Wikipedia under "POD" that seems to be related to pharmaceuticals. If it's a standard abbreviation, then it should be a link to a page describing it.

Do you mean "POM"? Could be "Prescription-Only Medication" ... Extenebris 17:10, 19 October 2006 (UTC)[reply]

IT MEANS PRESCRIPTION ONLY DRUG. —Preceding unsigned comment added by 117.212.46.29 (talk) 19:07, 27 April 2011 (UTC)[reply]

mode of action

It should be noted that clomifene has an effect on the hypothalamus as well- causing the hypothalamus to sense "low" levels of estrogen and therefor secrete GnRH in a higher frequency, which in turn causes a rise in gonadotropin release. It has an effect on the ovary and uterus as well.

Ormeloxifene main article needs editors

I've tried posting in Wikiproject:Clinical medicine, and have found few who know anything about ormeloxifene. Especially needed are chemists, scientists, and doctors who are knowledgable about this SERM. Thank you! Joie de Vivre 14:36, 14 December 2006 (UTC)[reply]

WP:LAME

Some anons keep on changing the spelling of "hot flashes" to "flushes" and back. If there was ever a silly edit war... But Googlefight (link) declares "hot flashes" unequivocal winner. JFW | T@lk 20:58, 12 April 2008 (UTC)[reply]

CURRENT Dx & Tx: OB&GYN uses "Hot Flushes" as the sub-chapter heading in symptoms of menopause, then uses "Hot Flahes" as a sub-chapter heading in differential diagnosis. CURRENT Medical Dx & Tx uses "Hot Flushes." Greenspan's Basic & Clinical Endocrinology uses "Hot Flashes." Williams Gynecology uses either/or. Goodman & Gilman's uses "hot flashes." Basic and Clinical Pharmacology uses "hot flushes." PubMed returns 2,518 hits for "hot flashes," and 1,464 hits for "hot flushes." Since it's a toss-up in the primary and secondary literature, and the Wikipedia page on the subject is already titled "hot flashes," it's probably best to leave it as "hot flashes" here, merely as a matter of internal consistency. Blahdenoma (talk) 07:05, 19 August 2011 (UTC)[reply]

Antiviral

Please somebody include the recent research on clomiphene. It was found to have antiviral activity against Ebola, HPV, and HIV (suppresses Rev protein). — Preceding unsigned comment added by 24.148.64.94 (talk) 05:20, 24 March 2019 (UTC)[reply]

Please find high quality secondary sources per WP:MEDRS Doc James (talk · contribs · email) 14:06, 24 March 2019 (UTC)[reply]

I added completely legitimate sources but that was removed by the above "expert" that didn't even make the effort to read them:,[1],[2].[3] Just because a study is not well known doesn't invalidate it. If you want 'secondary sources' find them yourself, instead of deleting vital information on fake grounds. So much for unbiased information on Wikipedia .... — Preceding unsigned comment added by 24.148.64.94 (talk) 17:30, 24 March 2019 (UTC)[reply]

References

  1. ^ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997570/
  2. ^ https://www.ncbi.nlm.nih.gov/pubmed/8835432
  3. ^ https://www.ncbi.nlm.nih.gov/pubmed/28331370

UCSF Foundations 2, 2019 - Group 5c, Goals

  • Separate mechanism of action from pharmacodynamics
  • Add pharmacokinetics
  • Brand name: add which one is the most common brandname in the US
  • Edit side effects
  • Add dosing information
  • Add contraindication, warnings and precaution
  • Make sure everything is in lay language

Msleee (talk) 21:53, 30 July 2019 (UTC)[reply]

Generally we put three bands in the infobox. An indepth discussion of brands can go in the body.
Generally we do not include dosing information.
I added contraindications to the body. Doc James (talk · contribs · email) 19:52, 31 July 2019 (UTC)[reply]

UCSF 5B Peer Review

  • 5C's group edits improved the article as described in the Wikipedia peer review “Guiding framework”. There are some terms that may need to be hyperlinked (to internal wikipedia links) in order for the audience to gain better understanding. Also the MOA section could be written in more lay language.
  • 5C has achieved most of their goals for improvement. 5C has edits left on side effects, contraindications, warnings, and precautions. Dosing information is no longer needed as stated above.
  • A. Draft submission reflects a neutral point of view. Well done! Tranhtruong (talk) 21:30, 5 August 2019 (UTC)[reply]
  • B. All citations added were cited from secondary sources and are easily accessible. Good job! --Kmiller22 (talk) 21:21, 5 August 2019 (UTC)[reply]
  • C. The edits are in English language that is at a level consistent with the rest of the page and the targeted audience that should have an understanding of basic pharmacokinetics and molecular biology terms. Style and formatting is good and similar to the rest of the page and of typical drug wiki pages. Addition of hyperlinks to related wiki pages are nice Kevindichosen1 (talk) 21:32, 5 August 2019 (UTC)[reply]
  • D. Most of the edits were made clearly and written with understanding of the cited material. The section on Mechanism of Action has some sentences that are written very similarly to what is written in UpToDate. (Ex. "Most evidence suggests..." and "In vitro data suggests...") - JVIDUYA (talk) 21:30, 5 August 2019 (UTC)[reply]

UCSF 5B Peer Review Response

Thank you for your feedback. We rephrased some sentences and added more information to hopefully make the section on mechanism of action easier for readers to understand.Msleee (talk) 17:27, 6 August 2019 (UTC)[reply]

Not exactly correct

This was added as contraindications "has abnormal uterine bleeding, ovarian cyst,"

Well ref says "contraindicated in patients with abnormal uterine bleeding of undetermined origin"

and

"ovarian cysts or enlargement not due to polycystic ovarian syndrome"

Which is obviously fairly different. Doc James (talk · contribs · email) 19:42, 31 July 2019 (UTC)[reply]

Have moved the full list of contraindications to the body. Doc James (talk · contribs · email) 19:49, 31 July 2019 (UTC)[reply]

RE: Not exactly correct

Apologies for the error, and thanks for making the correction for us! Vicknguy (talk) 20:25, 7 August 2019 (UTC)[reply]

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