Placental site nodule
|Placental site nodule|
|Micrograph of a placental site nodule (top of image). H&E stain.|
They are typically asymptomatic and found incidentally.
PSNs are intermediate trophoblastic remnants.
Typically, they consist of pink (hyaline) material using the standard stain and contain few cells. Bizarre multinucleated cells may be present; however, there is no mitotic activity. The differential diagnosis includes (cervical) squamous cell carcinoma, gestational trophoblastic disease, and exaggerated placental site.
PSN are benign. Once removed, they do not require any treatment and do not recur.