Chlordiazepoxide/clidinium

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Chlordiazepoxide/clidinium
Combination of
ChlordiazepoxideBenzodiazepine
Clidinium bromideAntimuscarinic
Names
Pronunciationklor dye az e pox' ide kli di' nee um[1]
Trade namesLibrax, Clindex, others[1]
Other namesChlordiazepoxide/clidinium bromide
Clinical data
Main usesIrritable bowel syndrome (IBS), gastroenteritis[2]
Side effectsDry mouth, blurry vision, constipation, trouble urinating[2]
Pregnancy
category
  • US: N (Not classified yet)[3]
Routes of
use
By mouth
External links
AHFS/Drugs.comMonograph
US NLMChlordiazepoxide/clidinium
MedlinePlusa601036
Legal
Legal status

Chlordiazepoxide/clidinium, sold under the brand name Librax among others, is a combination medication used to treat irritable bowel syndrome (IBS) and gastroenteritis.[2] It is not a preferred treatment.[2] While it has been used for peptic ulcer disease, there is no clear evidence of benefit.[2] It is taken by mouth usually three or four times daily.[2]

Common side effects include dry mouth, blurry vision, constipation, and trouble urinating.[2] Other side effects may include sleepiness, poor coordination, misuse, and trouble breathing.[2][1][4] It contains chlordiazepoxide, a benzodiazepine and clidinium bromide, an anticholinergic.[1]

The combination was approved for medical use in the United States in 1966.[5] It is available as a generic medication.[2] In the United States 60 pills of 5 mg chlordiazepoxide / 2.5 mg clidinium costs about 80 USD as of 2022.[6]

Medical uses

Chlordiazepoxide/clidinium bromide is indicated to control emotional and somatic factors in gastrointestinal disorders.[4] It may also be used as adjunctive therapy in the treatment of peptic ulcer and in the treatment of the irritable bowel syndrome (irritable colon, spastic colon, mucous colitis) and acute enterocolitis.[4]

Side effects

Chlordiazepoxide can be habit-forming. Tolerance may develop with long-term or excessive use, making this medication less effective. This medication must be taken regularly to be effective. Stopping the drug suddenly can worsen the condition and cause withdrawal symptoms (anxiousness, sleeplessness, and irritability).[1]

Mechanism of action

Chlordiazepoxide is a benzodiazepine class. Clidinium bromide is a synthetic quaternary ammonium antimuscarinic,[7] a sub-class of a family of drugs known as anticholinergics.

References

  1. 1.0 1.1 1.2 1.3 1.4 "Librax". MedlinePlus: US National library of medicine. Archived from the original on 5 July 2016. Retrieved 31 May 2013.
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 "Clidinium Monograph for Professionals". Drugs.com. Archived from the original on 28 August 2018. Retrieved 5 January 2022.
  3. "Chlordiazepoxide / clidinium Use During Pregnancy". Drugs.com. 18 September 2019. Archived from the original on 29 November 2020. Retrieved 15 August 2020.
  4. 4.0 4.1 4.2 "Librax- chlordiazepoxide hydrochloride and clidinium bromide capsule". DailyMed. 31 May 2020. Archived from the original on 8 August 2020. Retrieved 15 August 2020.
  5. "Librax: FDA-Approved Drugs". U.S. Food and Drug Administration (FDA). Archived from the original on 23 October 2020. Retrieved 15 August 2020.
  6. "Chlordiazepoxide / Clidinium Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 5 November 2016. Retrieved 5 January 2022.
  7. http://www.medscape.com/druginfo/monograph?cid=med&drugid=15881&drugname=Librax+(with+Clidinium)+Oral&monotype=monograph&monographid=384006 MedScape - Clidinium[dead link]

External links

Identifiers: