|Pronunciation||klor dye az e pox' ide kli di' nee um|
|Trade names||Librax, Clindex, others|
|Other names||Chlordiazepoxide/clidinium bromide|
|Main uses||Irritable bowel syndrome (IBS), gastroenteritis|
|Side effects||Dry mouth, blurry vision, constipation, trouble urinating|
Chlordiazepoxide/clidinium, sold under the brand name Librax among others, is a combination medication used to treat irritable bowel syndrome (IBS) and gastroenteritis. It is not a preferred treatment. While it has been used for peptic ulcer disease, there is no clear evidence of benefit. It is taken by mouth usually three or four times daily.
Common side effects include dry mouth, blurry vision, constipation, and trouble urinating. Other side effects may include sleepiness, poor coordination, misuse, and trouble breathing. It contains chlordiazepoxide, a benzodiazepine and clidinium bromide, an anticholinergic.
The combination was approved for medical use in the United States in 1966. It is available as a generic medication. In the United States 60 pills of 5 mg chlordiazepoxide / 2.5 mg clidinium costs about 80 USD as of 2022.
Chlordiazepoxide/clidinium bromide is indicated to control emotional and somatic factors in gastrointestinal disorders. It may also be used as adjunctive therapy in the treatment of peptic ulcer and in the treatment of the irritable bowel syndrome (irritable colon, spastic colon, mucous colitis) and acute enterocolitis.
Chlordiazepoxide can be habit-forming. Tolerance may develop with long-term or excessive use, making this medication less effective. This medication must be taken regularly to be effective. Stopping the drug suddenly can worsen the condition and cause withdrawal symptoms (anxiousness, sleeplessness, and irritability).
Mechanism of action
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