Protein-coding gene in the species Homo sapiens
Centrosome-associated protein 350 is a protein that in humans is encoded by the CEP350 gene .[5] [6] [7]
CEP350 is a large protein with a CAP-Gly domain typically found in cytoskeleton -associated proteins. It primarily localizes to the centrosome , a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. CEP350 is required to anchor microtubules at the centrosome. Furthermore, it increases the stability of growing centrioles .[8]
It is also implicated in the regulation of a class of nuclear hormone receptors in the nucleus. Several alternatively spliced transcript variants have been found, but their full-length nature has not been determined.[7]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000135837 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033671 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Yan X, Habedanck R, Nigg EA (Jan 2006). "A Complex of Two Centrosomal Proteins, CAP350 and FOP, Cooperates with EB1 in Microtubule Anchoring" . Mol Biol Cell . 17 (2): 634–44. doi :10.1091/mbc.E05-08-0810 . PMC 1356575 PMID 16314388 . ^ Patel H, Truant R, Rachubinski RA, Capone JP (Dec 2004). "Activity and subcellular compartmentalization of peroxisome proliferator-activated receptor alpha are altered by the centrosome-associated protein CAP350" . J Cell Sci . 118 (Pt 1): 175–86. doi :10.1242/jcs.01600 PMID 15615782 . ^ a b "Entrez Gene: CEP350 centrosomal protein 350kDa" .^ Le Clech, M (2008). "Role of CAP350 in centriolar tubule stability and centriole assembly" . PLOS ONE . 3 (12): e3855. Bibcode :2008PLoSO...3.3855L . doi :10.1371/journal.pone.0003855 PMC 2586089 PMID 19052644 .
External links Further reading
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